{"id":5742,"date":"2023-09-04T03:22:56","date_gmt":"2023-09-04T03:22:56","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/nlst-pathology\/"},"modified":"2023-09-13T12:05:44","modified_gmt":"2023-09-13T12:05:44","slug":"nlst-pathology","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/nlst-pathology\/","title":{"rendered":"NLST-PATHOLOGY"},"featured_media":0,"template":"","citation-tax":[],"cancer_types":false,"citations":[4738,4739,2925],"collection_doi":"10.7937\/TCIA.HMQ8-J677","collection_download_info":"
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<\/a><\/div>The Cancer Imaging Archive hosts pathology images from the National Lung Screening Trial<\/a>, in addition to the existing\u00a0radiology images<\/a> and a subset of the full clinical data.\u00a0 If you need the full clinical data,please visit the\u00a0Cancer Data Access System (CDAS)<\/a> system. \u00a0The NLST was conducted by two separate networks of screening centers: 1)\u00a0Lung Screening Study Network (LSS):10 centers and 34,612 participants; and 2)\u00a0American College of Radiology Imaging Network (ACRIN): 23 centers and 18,840 participants.\u00a0TCIA only hosts pathology data from LSS. The\u00a0ACRIN pathology images and data are not available through TCIA.<\/p>

As part of the pathology collection effort tissue, images, and data was obtained from 463 lung cancer patients (out of 1,284 total lung cancer patients in LSS).\u00a0 Note that nine of these 463 participants had two primary lung tumors; these are accessible through TCIA as an optional additional download for these nine participants.\u00a0<\/p>

About the Pathology Data<\/h3>

The NLST pathology specimen collection consists of biospecimens, images, and data for research.\u00a0 Near the conclusion of NLST activities, all available blocks of preserved lung tissue from NLST lung cancer patients were requested from pathology labs.\u00a0 Tissue cores were sampled from these donor blocks and placed into tissue microarrays (TMAs) and into Eppendorf tubes for analysis by the research community; the request process for the tissue specimens is under development as of October 2013.\u00a0The images were obtained as an intermediate step in TMA construction.\u00a0\u00a0A thin section was cut from each donor tissue block, stained with hematoxylin and eosin (H & E), and imaged using an Aperio ScanScope.<\/p>

Data Availability: <\/strong>A summary of the National Lung Screening Trial and its available datasets are provided on the Cancer Data Access System (CDAS)<\/a><\/u>. CDAS is maintained by Information Management System (IMS), contracted by the National Cancer Institute (NCI) as keepers and statistical analyzers of the NLST trial data.\u00a0 The full clinical data set from NLST is available through CDAS.\u00a0 Users of TCIA can download without restriction a publicly distributable subset of that clinical data, along with the CT and Histopathology images collected during the trial.\u00a0 (These previously were restricted.)<\/p><\/div>\n<\/div>\n

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<\/span>The Cancer Imaging Archive hosts pathology images from the National Lung Screening Trial<\/a>, in addition to the existing\u00a0radiology images<\/a> and a subset of the full clinical data.\u00a0 If you need the full clinical data,please visit the\u00a0Cancer Data Access System (CDAS)<\/a> system. \u00a0The NLST was conducted by two separate networks of screening centers: 1)\u00a0Lung Screening Study Network (LSS):10 centers and 34,612 participants; and 2)\u00a0American College of Radiology Imaging Network (ACRIN): 23 centers and 18,840 participants.\u00a0TCIA only hosts pathology data from LSS. The\u00a0ACRIN pathology images and data are not available through TCIA.<\/p>

As part of the pathology collection effort tissue, images, and data was obtained from 463 lung cancer patients (out of 1,284 total lung cancer patients in LSS).\u00a0 Note that nine of these 463 participants had two primary lung tumors; these are accessible through TCIA as an optional additional download for these nine participants.\u00a0<\/p>

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About the Pathology Data<\/h2>

The NLST pathology specimen collection consists of biospecimens, images, and data for research.\u00a0 Near the conclusion of NLST activities, all available blocks of preserved lung tissue from NLST lung cancer patients were requested from pathology labs.\u00a0 Tissue cores were sampled from these donor blocks and placed into tissue microarrays (TMAs) and into Eppendorf tubes for analysis by the research community; the request process for the tissue specimens is under development as of October 2013.\u00a0The images were obtained as an intermediate step in TMA construction.\u00a0\u00a0A thin section was cut from each donor tissue block, stained with hematoxylin and eosin (H & E), and imaged using an Aperio ScanScope.<\/p>

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Data Availability: <\/strong>A summary of the National Lung Screening Trial and its available datasets are provided on the Cancer Data Access System (CDAS)<\/a><\/u>. CDAS is maintained by Information Management System (IMS), contracted by the National Cancer Institute (NCI) as keepers and statistical analyzers of the NLST trial data.\u00a0 The full clinical data set from NLST is available through CDAS.\u00a0 Users of TCIA can download without restriction a publicly distributable subset of that clinical data, along with the CT and Histopathology images collected during the trial.\u00a0 (These previously were restricted.)<\/span><\/p><\/div>\n<\/div>\n

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