{"id":5689,"date":"2023-09-04T03:18:26","date_gmt":"2023-09-04T03:18:26","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/a091105\/"},"modified":"2023-09-13T12:03:13","modified_gmt":"2023-09-13T12:03:13","slug":"a091105","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/a091105\/","title":{"rendered":"A091105"},"featured_media":7669,"template":"","citation-tax":[],"cancer_types":["Non-Cancer"],"citations":[4635,4636,2925],"collection_doi":"10.7937\/0WF5-SJ50","collection_download_info":"This is a\u00a0<strong><u>limited access<\/u><\/strong>\u00a0data set.\u00a0To request access please register an account on the\u00a0<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0use the\u00a0\"Request Data\" link in the left side menu.\u00a0 Follow the on screen instructions, and enter <strong>NCT02066181<\/strong>\u00a0when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a href=\"mailto:NCINCTNDataArchive@mail.nih.gov\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.\n\nClick the Versions tab for more info about data releases.","collection_downloads":[5266],"full_export":"<h1 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-Summary\">Summary<\/h1><span class=\"confluence-embedded-file-wrapper image-right-wrapper confluence-embedded-manual-size\"><img class=\"confluence-embedded-image image-right\" draggable=\"false\" width=\"413\" src=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/embedded-page\/Public\/Sorafenib%20Tosylate%20in%20Treating%20Patients%20With%20Desmoid%20Tumors%20or%20Aggressive%20Fibromatosis%20(A091105)\/nctn%20logo.png?api=v2\"><\/span><p>This collection contains data from the <span style=\"color: rgb(0,0,0);\">Alliance for Clinical Trials in Oncology Clinical Trial<\/span> <a class=\"external-link\" href=\"https:\/\/clinicaltrials.gov\/show\/NCT02066181\" style=\"text-decoration: none;\" title=\"Current version of study NCT02066181 on ClinicalTrials.gov\" rel=\"nofollow\">NCT02066181<\/a><span style=\"color: rgb(0,0,0);\"><span>\u00a0<\/span> \u201cSorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis&quot;. Principal Investigator: Mrinal M Gounder. It was sponsored by NCI and performed by the Alliance for Clinical Trials in Oncology under study number A091105. This randomized phase III trial compares the effects, good and\/or bad, of sorafenib tosylate in treating patients with desmoid tumors or aggressive fibromatosis. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the proteins needed for cell growth. Select patient-level data from this trial is available via the following link: <\/span><span style=\"color: rgb(0,0,0);\">\u00a0<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266\" class=\"external-link\" rel=\"nofollow\">https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266<\/a>.<\/span><\/p><p style=\"text-align: justify;\"><span style=\"color: rgb(0,0,0);\"><strong>Trial Outcomes\u00a0<\/strong><strong>\u00a0<\/strong><\/span><\/p><p style=\"text-align: justify;\"><span style=\"color: rgb(0,0,0);\">Results of the trial have been reported in the following publications:<\/span><\/p><ul><li><span style=\"color: rgb(0,0,0);\">Mazza GL, Petersen MM, Ginos B, Langlais BT, Heon N, Gounder MM, Mahoney MR, Zoroufy AJ, Schwartz GK, Rogak LJ, Thanarajasingam G, Basch E, Dueck AC. Missing data strategies for the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in Alliance A091105 and COMET-2. Qual Life Res. 2022 Apr;31(4):1069-1080. doi: 10.1007\/s11136-021-02968-1. Epub 2021 Aug 21. Erratum in: Qual Life Res. 2021 Oct 11.<\/span><\/li><li><span style=\"color: rgb(0,0,0);\">Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC. Composite grading algorithm for the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Clin Trials. 2021 Feb;18(1):104-114. doi: 10.1177\/1740774520975120. Epub 2020 Dec 1.<\/span><\/li><li><span style=\"color: rgb(0,0,0);\">Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA, Gupta AA, Milhem MM, Conry RM, Movva S, Pishvaian MJ, Riedel RF, Sabagh T, Tap WD, Horvat N, Basch E, Schwartz LH, Maki RG, Agaram NP, Lefkowitz RA, Mazaheri Y, Yamashita R, Wright JJ, Dueck AC, Schwartz GK. Sorafenib for Advanced and Refractory Desmoid Tumors. N Engl J Med. 2018 Dec 20;379(25):2417-2428. doi: 10.1056\/NEJMoa1805052.\u00a0<\/span><\/li><\/ul><div class=\"tab-style-builtin\"><div class=\"localtabs-macro\"><div class=\"aui-tabs horizontal-tabs\" role=\"application\" data-aui-responsive=\"true\"><ul class=\"tabs-menu\"><li class=\"menu-item bv-localtab  active-tab \"><a href=\"#12766423865bddd45575248d5870e1bc3aebc8f82\"><strong>Data Access<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#1276642385c93d482dfc3447fad1ac8e7a0cb470c\"><strong>Detailed Description<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#127664238209181292fe9483990af4d913f44aa19\"><strong>Citations &amp; Data Usage Policy<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#127664238ee29454164044eaa94a9bc532557234e\"><strong>Versions<\/strong><\/a> <\/li><\/ul><div class=\"tabs-pane  active-pane \" id=\"12766423865bddd45575248d5870e1bc3aebc8f82\" active=\"true\" name=\"Data Access\" ><h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-DataAccess\">Data Access<\/h3><p><span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(33,37,41);\">This is a\u00a0<\/span><strong><u>limited access<\/u><\/strong><span style=\"color: rgb(33,37,41);\">\u00a0data set.\u00a0<\/span><span style=\"color: rgb(0,0,0);\">To request access please register an account on the\u00a0<a class=\"external-link\" style=\"text-decoration: none;\" href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\" rel=\"nofollow\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0<\/span><span style=\"color: rgb(0,0,0);\">use the\u00a0<\/span><span style=\"color: rgb(0,0,0);\">&quot;Request Data&quot; link in the left side menu.\u00a0 Follow the on screen instructions, and enter <strong>NCT02066181<\/strong><\/span><span style=\"color: rgb(0,0,0);\">\u00a0when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a rel=\"nofollow\" style=\"text-decoration: none;\" class=\"external-link\" href=\"mailto:NCINCTNDataArchive@mail.nih.gov\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.<\/span><\/span><\/p><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 54.3651%;\"><colgroup><col style=\"width: 15.5847%;\"\/><col style=\"width: 53.9358%;\"\/><col style=\"width: 30.4389%;\"\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Images\u00a0 (DICOM, 260 GB)<\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/127664238\/A091105%20February%202023%20manifest.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=A091105\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p><span style=\"color: rgb(33,37,41);text-decoration: none;\">(Download requires <\/span><a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" style=\"text-decoration: none;text-align: left;\" rel=\"nofollow\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/sites\/default\/files\/DUA\/NCTN_NCORP_Data_Archive_DUA_CA_v2019-06-12.pdf?version=1&amp;modificationDate=1652964581655&amp;api=v2\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive License (With Collaborative Agreement)<\/a><\/p><p><br\/><\/p><p><br\/><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p>Click the Versions tab for more info about data releases.<\/p><p>\n<h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-AdditionalResourcesforthisDataset\">Additional Resources for this Dataset<\/h3>\n<p>The National Cancer Institute (NCI) has created a centralized, controlled-access database, called the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/about-us\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive<\/a>, for storing and sharing datasets generated from clinical trials of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP).  Clinical data from the participants in this trial can be found at:\n<\/p><\/p><ul><li><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive<\/a><span>\u00a0<\/span>(Clinical Data)<\/li><\/ul><\/div><div class=\"tabs-pane \" id=\"1276642385c93d482dfc3447fad1ac8e7a0cb470c\" name=\"Detailed Description\" ><h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-DetailedDescription\">Detailed Description<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\"><p>Image Statistics<\/p><\/th><th class=\"confluenceTh\">Radiology Image Statistics<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Modalities<\/p><\/td><td class=\"confluenceTd\"><p>CT, MR<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Patients<\/p><\/td><td class=\"confluenceTd\"><p>83<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Studies<\/p><\/td><td class=\"confluenceTd\"><p>1140<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Series<\/p><\/td><td class=\"confluenceTd\"><p>11977<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Images<\/p><\/td><td class=\"confluenceTd\"><p>722626<\/p><\/td><\/tr><tr><td class=\"confluenceTd\">Images Size (GB)<\/td><td class=\"confluenceTd\">278<\/td><\/tr><\/tbody><\/table><\/div><p><h2 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-De-identificationofDICOMdates\">De-identification of DICOM dates<\/h2><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0<span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/span><\/span><\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the &quot;Days from registration&quot; would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h2 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-Insertionofcomputed&quot;REGISTRATION&quot;\/Daysoffsetfromregistration&quot;value\">Insertion of computed &quot;REGISTRATION&quot;\/Days offset from registration&quot; value<\/h2><p style=\"text-align: left;\">In addition to modifying the actual date fields in the DICOM header, the &quot;days from registration&quot; values are calculated and stored in the DICOM tag<strong> (0012,0052) <span style=\"color: rgb(34,34,34);\">Longitudinal Temporal Offset from Event<\/span><\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p style=\"text-align: left;\"><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p><p><br\/><\/p><\/p><\/div><div class=\"tabs-pane \" id=\"127664238209181292fe9483990af4d913f44aa19\" name=\"Citations BITVOODOO_ANDamp; Data Usage Policy\" ><h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-Citations&amp;DataUsagePolicy\">Citations &amp; Data Usage Policy<\/h3><p>\nThis is a limited access data set. Upon receiving access, you must abide by the terms of your <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/sites\/default\/files\/DUA\/NCTN_NCORP_Data_Archive_DUA_CA_v2019-06-12.pdf\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive\u2019s Data Use Agreement (DUA)<\/a>. You are not allowed to redistribute the data or use it for other purposes. Attribution should include references to the following citations:<\/p><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Data Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Gounder, M. M., Mahoney, M. R., Van Tine, B. A., Ravi, V., Attia, S., Deshpande, H. A., Gupta, A. A., Milhem, M. M., Conry, R. M., Movva, S., Pishvaian, M. J., Riedel, R. F., Sabagh, T., Tap, W. D., Horvat, N., Basch, E., Schwartz, L. H., Maki, R. G., Agaram, N. P., \u2026 Schwartz, G. K. (2023). Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis (A091105) (Version 1) [Data set]. The Cancer Imaging Archive.<\/span> <a href=\"https:\/\/doi.org\/10.7937\/0WF5-SJ50\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.7937\/0WF5-SJ50<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Publication Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Gounder, M. M., Mahoney, M. R., Van Tine, B. A., Ravi, V., Attia, S., Deshpande, H. A., Gupta, A. A., Milhem, M. M., Conry, R. M., Movva, S., Pishvaian, M. J., Riedel, R. F., Sabagh, T., Tap, W. D., Horvat, N., Basch, E., Schwartz, L. H., Maki, R. G., Agaram, N. P., \u2026 Schwartz, G. K. (2018). Sorafenib for Advanced and Refractory Desmoid Tumors. In New England Journal of Medicine (Vol. 379, Issue 25, pp. 2417\u20132428). Massachusetts Medical Society<\/span>. <a href=\"https:\/\/doi.org\/10.1056\/nejmoa1805052\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1056\/nejmoa1805052<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">TCIA Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., &amp; Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045\u20131057). Springer Science and Business Media LLC.<\/span> <a href=\"https:\/\/doi.org\/10.1007\/s10278-013-9622-7\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s10278-013-9622-7<\/a><\/span><\/p><\/div><\/div><h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-OtherPublicationsUsingThisData\">Other Publications Using This Data<\/h3><p><span>TCIA maintains\u00a0<\/span><a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\" class=\"external-link\" rel=\"nofollow\">a list of publications<\/a><span> which leverage TCIA data. <\/span> If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\" rel=\"nofollow\"> contact the TCIA Helpdesk<\/a>.<\/p><\/div><div class=\"tabs-pane \" id=\"127664238ee29454164044eaa94a9bc532557234e\" name=\"Versions\" ><h3 id=\"SorafenibTosylateinTreatingPatientsWithDesmoidTumorsorAggressiveFibromatosis(A091105)-Version1(Current):Updated2023\/02\/10\">Version 1 (Current): Updated 2023\/02\/10<\/h3><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 36.813%;\"><colgroup><col style=\"width: 26.4084%;\"\/><col style=\"width: 39.1485%;\"\/><col style=\"width: 34.4318%;\"\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Images (DICOM, 260 GB)<\/p><p><br\/><\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/127664238\/A091105%20February%202023%20manifest.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=A091105\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p><span style=\"color: rgb(33,37,41);text-decoration: none;\">(Download requires\u00a0<\/span><span style=\"color: rgb(33,37,41);text-decoration: none;\">the<span>\u00a0<\/span><\/span><a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" rel=\"nofollow\" style=\"text-decoration: none;text-align: left;\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/sites\/default\/files\/DUA\/NCTN_NCORP_Data_Archive_DUA_CA_v2019-06-12.pdf?version=1&amp;modificationDate=1652964581655&amp;api=v2\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive License (With Collaborative Agreement)<\/a><\/p><p><br\/><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><\/div><\/div><p><br\/><\/p><p><br\/><\/p>","versions":false,"additional_resources":"The National Cancer Institute (NCI) has created a centralized, controlled-access database, called the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/about-us\">NCTN\/NCORP Data Archive<\/a>, for storing and sharing datasets generated from clinical trials of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP).  Clinical data from the participants in this trial can be found at:\n\n \n<ul><li><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266\">NCTN\/NCORP Data Archive<\/a>\u00a0(Clinical Data)<\/li><\/ul>","cancer_locations":["Various"],"collection_page_accessibility":"Public","publications_related":"","version_change_log":"","version_change_log_archived":"","analysis_results":"","collection_status":"Complete","publications_using":"TCIA maintains\u00a0<a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> which leverage TCIA data.  If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\"> contact the TCIA Helpdesk<\/a>.","species":["Human"],"collection_title":"Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis","detailed_description":"<h3>De-identification of DICOM dates<\/h3><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the \"Days from registration\" would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h3>Insertion of computed \"REGISTRATION\"\/Days offset from registration\" value<\/h3><p>In addition to modifying the actual date fields in the DICOM header, the \"days from registration\" values are calculated and stored in the DICOM tag<strong> (0012,0052) Longitudinal Temporal Offset from Event<\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p>","related_analysis_results":false,"subjects":"83","collection_short_title":"A091105","data_types":["CT","MR"],"date_updated":"2023-09-13","collection_browse_title":"","supporting_data":["Clinical"],"collection_featured_image":{"ID":"7669","post_author":"6","post_date":"2023-09-13 03:38:25","post_date_gmt":"2023-09-13 03:38:25","post_content":"","post_title":"nctn-logo","post_excerpt":"","post_status":"inherit","comment_status":"open","ping_status":"closed","post_password":"","post_name":"nctn-logo","to_ping":"","pinged":"","post_modified":"2023-09-13 11:56:51","post_modified_gmt":"2023-09-13 11:56:51","post_content_filtered":"","post_parent":"5551","guid":"https:\/\/cm.vastapps.dev\/wp-content\/uploads\/nctn-logo.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"7669"},"collection_summary":"<p>This collection contains data from the Alliance for Clinical Trials in Oncology Clinical Trial <a href=\"https:\/\/clinicaltrials.gov\/show\/NCT02066181\" title=\"Current version of study NCT02066181 on ClinicalTrials.gov\">NCT02066181<\/a>\u00a0 \u201cSorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis\". Principal Investigator: Mrinal M Gounder. It was sponsored by NCI and performed by the Alliance for Clinical Trials in Oncology under study number A091105. This randomized phase III trial compares the effects, good and\/or bad, of sorafenib tosylate in treating patients with desmoid tumors or aggressive fibromatosis. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the proteins needed for cell growth. Select patient-level data from this trial is available via the following link: \u00a0<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266\">https:\/\/nctn-data-archive.nci.nih.gov\/node\/1266<\/a>.<\/p><p><strong>Trial Outcomes\u00a0<\/strong><strong>\u00a0<\/strong><\/p><p>Results of the trial have been reported in the following publications:<\/p><ul><li>Mazza GL, Petersen MM, Ginos B, Langlais BT, Heon N, Gounder MM, Mahoney MR, Zoroufy AJ, Schwartz GK, Rogak LJ, Thanarajasingam G, Basch E, Dueck AC. Missing data strategies for the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in Alliance A091105 and COMET-2. Qual Life Res. 2022 Apr;31(4):1069-1080. doi: 10.1007\/s11136-021-02968-1. Epub 2021 Aug 21. Erratum in: Qual Life Res. 2021 Oct 11.<\/li><li>Basch E, Becker C, Rogak LJ, Schrag D, Reeve BB, Spears P, Smith ML, Gounder MM, Mahoney MR, Schwartz GK, Bennett AV, Mendoza TR, Cleeland CS, Sloan JA, Bruner DW, Schwab G, Atkinson TM, Thanarajasingam G, Bertagnolli MM, Dueck AC. Composite grading algorithm for the National Cancer Institute's Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Clin Trials. 2021 Feb;18(1):104-114. doi: 10.1177\/1740774520975120. Epub 2020 Dec 1.<\/li><li>Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA, Gupta AA, Milhem MM, Conry RM, Movva S, Pishvaian MJ, Riedel RF, Sabagh T, Tap WD, Horvat N, Basch E, Schwartz LH, Maki RG, Agaram NP, Lefkowitz RA, Mazaheri Y, Yamashita R, Wright JJ, Dueck AC, Schwartz GK. Sorafenib for Advanced and Refractory Desmoid Tumors. N Engl J Med. 2018 Dec 20;379(25):2417-2428. doi: 10.1056\/NEJMoa1805052.\u00a0<\/li><\/ul>","collection_acknowledgements":"","collection_funding":"","hide_from_browse_table":[],"_links":{"self":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections\/5689"}],"collection":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections"}],"about":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/types\/tcia_collection"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media\/7669"}],"wp:attachment":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media?parent=5689"}],"wp:term":[{"taxonomy":"tcia_citation_tax","embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/v1\/citation-tax?post=5689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}