{"id":5685,"date":"2023-09-04T03:17:56","date_gmt":"2023-09-04T03:17:56","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/vestibular-schwannoma-seg\/"},"modified":"2023-09-13T12:03:00","modified_gmt":"2023-09-13T12:03:00","slug":"vestibular-schwannoma-seg","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/vestibular-schwannoma-seg\/","title":{"rendered":"VESTIBULAR-SCHWANNOMA-SEG"},"featured_media":8200,"template":"","citation-tax":[],"cancer_types":["Vestibular Schwannoma (non-cancer)"],"citations":[4628,4629,2925],"collection_doi":"10.7937\/TCIA.9YTJ-5Q73","collection_download_info":"Click the Versions tab for more info about data releases.","collection_downloads":[5251,5252,5254,5255],"full_export":"<h2 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-Summary\">Summary<\/h2><div class=\"wiki-content\"><p style=\"text-align: left;\">This collection contains a labeled dataset of MRI images collected on <span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">242<\/span>\u00a0<\/span>consecutive patients with vestibular schwannoma (VS) undergoing Gamma Knife stereotactic radiosurgery (GK SRS). The structural images included contrast-enhanced T1-weighted (ceT1) images and high-resolution T2-weighted (hrT2) images. Each imaging dataset is accompanied by the patient\u2019s radiation therapy (RT) dataset including the RTDose, RTStructures and RTPlan. <span style=\"color: rgb(0,0,0);\">Additionally, registration matrices (.tfm format) and segmentation contour lines (JSON format) are provided and described<span>\u00a0<\/span><\/span>below<span style=\"color: rgb(0,0,0);\">.\u00a0<\/span>All structures were manually segmented in consensus by the treating neurosurgeon and physicist using both the ceT1 and hrT2 images. The value of this collection is to provide clinical image data including fully annotated tumour segmentations to facilitate the development and validation of automated segmentation frameworks. It may also be used for research relating to radiation treatment.<span class=\"confluence-embedded-file-wrapper image-right-wrapper confluence-embedded-manual-size\"><img class=\"confluence-embedded-image image-right\" draggable=\"false\" width=\"450\" src=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/embedded-page\/Public\/Segmentation%20of%20Vestibular%20Schwannoma%20from%20Magnetic%20Resonance%20Imaging:%20An%20Open%20Annotated%20Dataset%20and%20Baseline%20Algorithm%20(Vestibular-Schwannoma-SEG)\/VS_example_with_caption.png?api=v2\"><\/span><\/p><p style=\"text-align: left;\">Imaging data from consecutive patients with a single sporadic VS treated with GK SRS between the years of\u00a0<span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">2012<\/span> <span style=\"color: rgb(0,0,0);\">and 2018<\/span><\/span><span style=\"color: rgb(255,0,0);\">\u00a0<\/span>were screened for the study. All adult patients older than 18 years with a single unilateral VS treated with GK SRS were eligible for inclusion in the study, including patients who had previously undergone operative surgical treatment. In total, 248 patients met these initial inclusion criteria including 51 patients who had previously undergone surgery. Patients were only included in the study if their pre-treatment image acquisition dataset was complete;\u00a0<span style=\"color: rgb(33,37,41);\">4 patients were thus excluded because of incomplete datasets and 2 further patients were excluded because the tumour was not completely contained in the image field of view.\u00a0<\/span><span style=\"letter-spacing: 0.0px;\">The images were obtained on a 32-channel Siemens Avanto 1.5T scanner using a Siemens single-channel head coil.<\/span><\/p><ul style=\"text-align: left;\"><li>Contrast-enhanced T1-weighted imaging was performed with an MPRAGE sequence with TR \/ TE \/ TI = 1900 ms \/ 2.97 ms \/ 1100 ms, in-plane resolution of 0.4 \u00d7 0.4 mm, in-plane matrix of 512 \u00d7 512, and slice thickness of 1.0\u20131.5 mm<\/li><li>High-resolution T2-weighted imaging was performed with a 3D CISS or FIESTA sequence with TR \/ TE 9.4 ms \/ 4.23 ms, in-plane resolution of approximately 0.5 \u00d7 0.5 mm, an in-plane matrix of 384 \u00d7 384 or 448 \u00d7 448, and slice thickness of 1.0\u20131.5 mm.<\/li><\/ul><p style=\"text-align: left;\">All manual segmentations were performed using Gamma Knife planning software (Leksell GammaPlan, Elekta, Sweden) that employs an in-plane semiautomated segmentation method. Using this software, each axial slice was manually segmented in turn.<\/p><h4 style=\"text-align: left;\" id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-RegistrationmatricesandJSONcontours\">Registration matrices and\u00a0JSON contours<\/h4><p><u>Registration Matrices<\/u>:<span>\u00a0<\/span>For each subject and each modality there is a text file named\u00a0inv_T1_LPS_to_T2_LPS.tfm or\u00a0inv_T2_LPS_to_T1_LPS.tfm.<span>\u00a0<\/span>The files\u00a0specify affine transformation matrices that can be used to co-register the T1 image to the\u00a0T2 image and vice versa.\u00a0The file format is a standard format defined by the Insight Toolkit (ITK) library.\u00a0The matrices are\u00a0the result of the co-registration of fiducials of the Leksell Stereotactic System MR Indicator box into which the patient\u2019s head\u00a0is fixed during image acquisition. The localization of fiducials and co-registration was performed automatically by the LeksellGammaPlan software.<\/p><p><u>Contours<\/u>:\u00a0For each subject and each modality there is a text file named\u00a0contours.json.<span>\u00a0<\/span>These<span>\u00a0<\/span>contour files in the T1 and T2 folder contain\u00a0the contour points of the segmented structures in\u00a0JavaScript Object Notation (JSON) format, mapped in the coordinate frames of the T1 image and the T2 image, respectively.\u00a0There can be small differences between the contour points of the RTSTRUCT and the contour points of the JSON files as explained in the following:<br\/>In most cases, the tumour was segmented on the T1 image while the cochlea was typically segmented on the T2 image. This\u00a0meant that some contour lines (typically for the tumour) were coplanar with the slices of the T1 image while others (typically\u00a0for the cochlea) were coplanar with T2 slices. After co-registration, the (un-resampled) slices of the T1 and T2 image generally\u00a0did not coincide; for example,\u00a0due to different image position and, occasionally, slice thickness. Therefore, the combined co-registered contour lines were neither jointly coplanar with the T1 nor with the T2 image slices.\u00a0Upon export of the segmentations in a given target\u00a0space, the\u00a0LeksellGammaPlan\u00a0software interpolates between the original contour lines to create new slice-aligned contour lines\u00a0in the target image space (T1 or T2). This results in the interpolated slice-aligned contour lines found in the RTSTRUCTs. In contrast, the contours in the JSON files were not interpolated after co-registration, and therefore describe the original\u00a0(potentially off-target-space-slice) manual segmentation accurately.<\/p><h3 style=\"text-align: left;\" id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-Relatedsoftware\">Related software<\/h3><p style=\"text-align: left;\"><span style=\"color: rgb(0,0,0);\">Please see the <a href=\"https:\/\/github.com\/KCL-BMEIS\/VS_Seg\" class=\"external-link\" rel=\"nofollow\">github respository link<\/a> which contains a script to organize the downloaded data into a more convenient folder structure and a script to\u00a0perform<span>\u00a0<\/span>co-registration based on the .tfm files<span>\u00a0<\/span>and to convert the downloaded DICOM images and JSON contours into NIFTI format. Moreover, the repository contains an algorithm for automatic segmentation of VS with deep learning, adapted to this data set. The applied neural network is based on the 2.5D UNet described in &quot;<a href=\"https:\/\/doi.org\/10.3171\/2019.9.jns191949\" class=\"external-link\" rel=\"nofollow\">An artificial intelligence framework for automatic segmentation and volumetry of vestibular schwannomas from contrast-enhanced T1-weighted and high-resolution T2-weighted MRI<\/a>&quot;<em> (<\/em>Shapey, et al., 2021<em>)<\/em>\u00a0and has been adapted to yield improved segmentation results. Our implementation uses MONAI, a freely available, PyTorch-based framework for deep learning in healthcare imaging (<\/span><a href=\"https:\/\/monai.io\/\" class=\"external-link\" rel=\"nofollow\">Project MONAI<\/a><span style=\"color: rgb(0,0,0);\">). This new implementation was devised to provide a starting point for researchers interested in automatic segmentation using state-of-the art deep learning frameworks for medical image processing.\u00a0<\/span><\/p><p style=\"text-align: left;\"><span style=\"font-size: 16.0px;font-weight: bold;\">Acknowledgements<\/span><\/p><p><span style=\"color: rgb(0,0,0);\">This work was supported by Wellcome Trust (203145Z\/16\/Z, 203148\/Z\/16\/Z, WT106882), EPSRC (NS\/A000050\/1, NS\/A000049\/1) and MRC (<\/span><span style=\"color: rgb(0,0,0);\"><span>MC_PC_180520)\u00a0<\/span><\/span><span style=\"color: rgb(0,0,0);\">funding. Tom Vercauteren is also<span>\u00a0<\/span><\/span><span style=\"color: rgb(0,0,0);\">supported by a Medtronic\/Royal Academy of Engineering Research Chair (RCSRF1819\\7\\34).<\/span><\/p><div class=\"tab-style-builtin\"><div class=\"localtabs-macro\"><div class=\"aui-tabs horizontal-tabs\" role=\"application\" data-aui-responsive=\"true\"><ul class=\"tabs-menu\"><li class=\"menu-item bv-localtab  active-tab \"><a href=\"#70229053128a5ccd68a44d1db67eb3f2b0f44641\"><strong>Data Access<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#70229053ad879e32af2546af90b8d440d3c6554d\"><strong>Detailed Description<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#702290533208e4065bac4f6e81321d3a68877f6a\"><strong>Citations &amp; Data Usage Policy<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#7022905365e7cb3d95ca4cfb8359564ae33fe141\"><strong>Versions<\/strong><\/a> <\/li><\/ul><div class=\"tabs-pane  active-pane \" id=\"70229053128a5ccd68a44d1db67eb3f2b0f44641\" active=\"true\" name=\"Data Access\" ><h3 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-DataAccess\">Data Access<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\"><p><span style=\"color: rgb(33,37,41);\">Images and Radiation Therapy Structures\u00a0<\/span>(DICOM, 26 GB)<\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=Vestibular-Schwannoma-SEG\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG%20Feb%202021%20manifest.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Directory names mapping to modality (.csv)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/DirectoryNamesMappingModality.csv?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Registration Matrices (.tfm, zip, 257 KB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG_matrices%20Mar%202021.zip?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Contours (JSON, zip, 16.7 MB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG%20contours%20Mar%202021.zip?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p>Click the Versions tab for more info about data releases.<\/p><p>\n<h3 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-AdditionalResourcesforthisDataset\">Additional Resources for this Dataset<\/h3>\n<p>The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.<\/p><\/p><ul><li class=\"auto-cursor-target\"><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=vestibular_schwannoma_seg\" class=\"external-link\" rel=\"nofollow\">Imaging Data Commons (IDC)<\/a> (Imaging Data)<\/li><\/ul><\/div><div class=\"tabs-pane \" id=\"70229053ad879e32af2546af90b8d440d3c6554d\" name=\"Detailed Description\" ><h3 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-DetailedDescription\">Detailed Description<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup> <col style=\"width: 164.0px;\"\/> <col style=\"width: 30.0px;\"\/> <\/colgroup><tbody><tr><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><div class=\"tablesorter-header-inner\"><p>Image Statistics<\/p><\/div><\/div><\/th><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><div class=\"tablesorter-header-inner\"><p><br\/><\/p><\/div><\/div><\/th><\/tr><tr><td class=\"confluenceTd\"><p>Modalities<\/p><\/td><td class=\"confluenceTd\"><p>MR, RTSTRUCT, RTDOSE, RTPLAN<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Participants<\/p><\/td><td class=\"confluenceTd\"><p>242<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Studies<\/p><\/td><td class=\"confluenceTd\"><p>242<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Series<\/p><\/td><td class=\"confluenceTd\"><p>1936<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Images<\/p><\/td><td class=\"confluenceTd\"><p>48582<\/p><\/td><\/tr><tr><td colspan=\"1\" class=\"confluenceTd\">Images Size (GB)<\/td><td colspan=\"1\" class=\"confluenceTd\">26<\/td><\/tr><\/tbody><\/table><\/div><\/div><div class=\"tabs-pane \" id=\"702290533208e4065bac4f6e81321d3a68877f6a\" name=\"Citations BITVOODOO_ANDamp; Data Usage Policy\" ><h3 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-Citations&amp;DataUsagePolicy\">Citations &amp; Data Usage Policy<\/h3><p>\n<p>\nUsers must abide by the <a href=\"https:\/\/wiki.cancerimagingarchive.net\/x\/c4hF\" class=\"external-link\" rel=\"nofollow\">TCIA Data Usage Policy and Restrictions<\/a>. Attribution should include references to the following citations:\n<\/p><\/p><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Data Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p>Shapey, J., Kujawa, A., Dorent, R., Wang, G., Bisdas, S., Dimitriadis, A., Grishchuck, D., Paddick, I., Kitchen, N., Bradford, R., Saeed, S., Ourselin, S., &amp; Vercauteren, T. (2021). Segmentation of Vestibular Schwannoma from Magnetic Resonance Imaging: An Open Annotated Dataset and Baseline Algorithm [Data set]. The Cancer Imaging Archive. <a href=\"https:\/\/doi.org\/10.7937\/TCIA.9YTJ-5Q73\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.7937\/TCIA.9YTJ-5Q73<\/a>\u00a0<\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Publication Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Shapey, J., Kujawa, A., Dorent, R., Wang, G., Dimitriadis, A., Grishchuk, D., Paddick, I., Kitchen, N., Bradford, R., Saeed, S. R., Bisdas, S., Ourselin, S., &amp; Vercauteren, T. (2021). Segmentation of vestibular schwannoma from MRI, an open annotated dataset and baseline algorithm. In Scientific Data (Vol. 8, Issue 1). Springer Science and Business Media LLC.<\/span> <a href=\"https:\/\/doi.org\/10.1038\/s41597-021-01064-w\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1038\/s41597-021-01064-w<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">TCIA Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., &amp; Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. Journal of Digital Imaging, 26(6), 1045\u20131057.<\/span> <a href=\"https:\/\/doi.org\/10.1007\/s10278-013-9622-7\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s10278-013-9622-7<\/a><\/span><\/p><\/div><\/div><p class=\"auto-cursor-target\"><span style=\"font-size: 16.0px;font-weight: bold;letter-spacing: -0.006em;\">Other Publications Using This Data<\/span><\/p><p><span>TCIA maintains<\/span> <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\" class=\"external-link\" rel=\"nofollow\"> a list of publications<\/a> <span> which leverage TCIA data. <\/span> If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\" rel=\"nofollow\"> contact the TCIA Helpdesk<\/a>.<\/p><p><span style=\"color: rgb(33,37,41);\"><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Shapey, J., Wang, G., Dorent, R., Dimitriadis, A., Li, W., Paddick, I., Kitchen, N., Bisdas, S., Saeed, S. R., Ourselin, S., Bradford, R., &amp; Vercauteren, T. (2021). An artificial intelligence framework for automatic segmentation and volumetry of vestibular schwannomas from contrast-enhanced T1-weighted and high-resolution T2-weighted MRI. Journal of Neurosurgery, 134(1), 171\u2013179<\/span>. <a href=\"https:\/\/doi.org\/10.3171\/2019.9.jns191949\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.3171\/2019.9.jns191949<\/a><\/span><\/span><\/p><\/div><div class=\"tabs-pane \" id=\"7022905365e7cb3d95ca4cfb8359564ae33fe141\" name=\"Versions\" ><h3 id=\"SegmentationofVestibularSchwannomafromMagneticResonanceImaging:AnOpenAnnotatedDatasetandBaselineAlgorithm(VestibularSchwannomaSEG)-Version2(Current):Updated2021\/03\/17\">Version 2 (Current): Updated 2021\/03\/17<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\"><span>Data Type<\/span><\/th><th class=\"confluenceTh\"><span>Download all or Query\/Filter<\/span><\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\"><p><span style=\"color: rgb(33,37,41);\">Images and Radiation Therapy Structures\u00a0<\/span>(DICOM, 26 GB)<\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=Vestibular-Schwannoma-SEG\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG%20Feb%202021%20manifest.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Directory names mapping to modality (.csv)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/DirectoryNamesMappingModality.csv?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Registration Matrices (.tfm, zip, 257 KB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG_matrices%20Mar%202021.zip?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Contours (JSON, zip, 16.7 MB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG%20contours%20Mar%202021.zip?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 4.0<\/a><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p><span style=\"color: rgb(0,0,0);\">Registration Matrices (.tfm) and Contours (JSON) were added to the dataset.<\/span><\/p><p><span style=\"font-size: 16.0px;font-weight: bold;letter-spacing: -0.006em;\">Version 1: Updated 2021\/02\/26<\/span><\/p><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup> <col\/> <col\/> <\/colgroup><tbody><tr><th class=\"confluenceTh\"><span>Data Type<\/span><\/th><th class=\"confluenceTh\"><span>Download all or Query\/Filter<\/span><\/th><\/tr><tr><td class=\"confluenceTd\"><p><span style=\"color: rgb(33,37,41);\">Images and Radiation Therapy Structures\u00a0<\/span>(DICOM, 26 GB)<\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=Vestibular-Schwannoma-SEG\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/Vestibular-Schwannoma-SEG%20Feb%202021%20manifest.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><\/tr><tr><td class=\"confluenceTd\">Directory names mapping to modality (.csv)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><br\/>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/70229053\/DirectoryNamesMappingModality.csv?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><\/div><\/div><\/div><p><br\/><\/p><p><br\/><\/p><p><br\/><\/p><p><br\/><\/p><p><br\/><\/p>","versions":false,"additional_resources":"The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\n \n<ul><li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=vestibular_schwannoma_seg\">Imaging Data Commons (IDC)<\/a> (Imaging Data)<\/li><\/ul>","cancer_locations":["Ear"],"collection_page_accessibility":"Public","publications_related":"","version_change_log":"","version_change_log_archived":"","analysis_results":"","collection_status":"Complete","publications_using":"","species":["Human"],"collection_title":"Segmentation of Vestibular Schwannoma from Magnetic Resonance Imaging: An Open Annotated Dataset and Baseline Algorithm","detailed_description":"","related_analysis_results":false,"subjects":"242","collection_short_title":"Vestibular-Schwannoma-SEG","data_types":["MR","RTSTRUCT","RTPLAN","RTDOSE"],"date_updated":"2023-09-13","collection_browse_title":"","supporting_data":["Image Analyses"],"collection_featured_image":{"ID":"8200","post_author":"6","post_date":"2023-09-13 03:59:13","post_date_gmt":"2023-09-13 03:59:13","post_content":"","post_title":"VS_example_with_caption","post_excerpt":"","post_status":"inherit","comment_status":"open","ping_status":"closed","post_password":"","post_name":"vs_example_with_caption","to_ping":"","pinged":"","post_modified":"2023-09-13 12:03:00","post_modified_gmt":"2023-09-13 12:03:00","post_content_filtered":"","post_parent":"5685","guid":"https:\/\/cm.vastapps.dev\/wp-content\/uploads\/VS_example_with_caption.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"8200"},"collection_summary":"This collection contains a labeled dataset of MRI images collected on 242\u00a0consecutive patients with vestibular schwannoma (VS) undergoing Gamma Knife stereotactic radiosurgery (GK SRS). The structural images included contrast-enhanced T1-weighted (ceT1) images and high-resolution T2-weighted (hrT2) images. Each imaging dataset is accompanied by the patient\u2019s radiation therapy (RT) dataset including the RTDose, RTStructures and RTPlan. Additionally, registration matrices (.tfm format) and segmentation contour lines (JSON format) are provided and described\u00a0below.\u00a0All structures were manually segmented in consensus by the treating neurosurgeon and physicist using both the ceT1 and hrT2 images. The value of this collection is to provide clinical image data including fully annotated tumour segmentations to facilitate the development and validation of automated segmentation frameworks. It may also be used for research relating to radiation treatment.<p>Imaging data from consecutive patients with a single sporadic VS treated with GK SRS between the years of\u00a02012 and 2018\u00a0were screened for the study. All adult patients older than 18 years with a single unilateral VS treated with GK SRS were eligible for inclusion in the study, including patients who had previously undergone operative surgical treatment. In total, 248 patients met these initial inclusion criteria including 51 patients who had previously undergone surgery. Patients were only included in the study if their pre-treatment image acquisition dataset was complete;\u00a04 patients were thus excluded because of incomplete datasets and 2 further patients were excluded because the tumour was not completely contained in the image field of view.\u00a0The images were obtained on a 32-channel Siemens Avanto 1.5T scanner using a Siemens single-channel head coil.<\/p><ul><li>Contrast-enhanced T1-weighted imaging was performed with an MPRAGE sequence with TR \/ TE \/ TI = 1900 ms \/ 2.97 ms \/ 1100 ms, in-plane resolution of 0.4 \u00d7 0.4 mm, in-plane matrix of 512 \u00d7 512, and slice thickness of 1.0\u20131.5 mm<\/li><li>High-resolution T2-weighted imaging was performed with a 3D CISS or FIESTA sequence with TR \/ TE 9.4 ms \/ 4.23 ms, in-plane resolution of approximately 0.5 \u00d7 0.5 mm, an in-plane matrix of 384 \u00d7 384 or 448 \u00d7 448, and slice thickness of 1.0\u20131.5 mm.<\/li><\/ul><p>All manual segmentations were performed using Gamma Knife planning software (Leksell GammaPlan, Elekta, Sweden) that employs an in-plane semiautomated segmentation method. Using this software, each axial slice was manually segmented in turn.<\/p><h4>Registration matrices and\u00a0JSON contours<\/h4><p><u>Registration Matrices<\/u>:\u00a0For each subject and each modality there is a text file named\u00a0inv_T1_LPS_to_T2_LPS.tfm or\u00a0inv_T2_LPS_to_T1_LPS.tfm.\u00a0The files\u00a0specify affine transformation matrices that can be used to co-register the T1 image to the\u00a0T2 image and vice versa.\u00a0The file format is a standard format defined by the Insight Toolkit (ITK) library.\u00a0The matrices are\u00a0the result of the co-registration of fiducials of the Leksell Stereotactic System MR Indicator box into which the patient\u2019s head\u00a0is fixed during image acquisition. The localization of fiducials and co-registration was performed automatically by the LeksellGammaPlan software.<\/p><p><u>Contours<\/u>:\u00a0For each subject and each modality there is a text file named\u00a0contours.json.\u00a0These\u00a0contour files in the T1 and T2 folder contain\u00a0the contour points of the segmented structures in\u00a0JavaScript Object Notation (JSON) format, mapped in the coordinate frames of the T1 image and the T2 image, respectively.\u00a0There can be small differences between the contour points of the RTSTRUCT and the contour points of the JSON files as explained in the following:<br\/>In most cases, the tumour was segmented on the T1 image while the cochlea was typically segmented on the T2 image. This\u00a0meant that some contour lines (typically for the tumour) were coplanar with the slices of the T1 image while others (typically\u00a0for the cochlea) were coplanar with T2 slices. After co-registration, the (un-resampled) slices of the T1 and T2 image generally\u00a0did not coincide; for example,\u00a0due to different image position and, occasionally, slice thickness. Therefore, the combined co-registered contour lines were neither jointly coplanar with the T1 nor with the T2 image slices.\u00a0Upon export of the segmentations in a given target\u00a0space, the\u00a0LeksellGammaPlan\u00a0software interpolates between the original contour lines to create new slice-aligned contour lines\u00a0in the target image space (T1 or T2). This results in the interpolated slice-aligned contour lines found in the RTSTRUCTs. In contrast, the contours in the JSON files were not interpolated after co-registration, and therefore describe the original\u00a0(potentially off-target-space-slice) manual segmentation accurately.<\/p><h3>Related software<\/h3><p>Please see the <a href=\"https:\/\/github.com\/KCL-BMEIS\/VS_Seg\">github respository link<\/a> which contains a script to organize the downloaded data into a more convenient folder structure and a script to\u00a0perform\u00a0co-registration based on the .tfm files\u00a0and to convert the downloaded DICOM images and JSON contours into NIFTI format. Moreover, the repository contains an algorithm for automatic segmentation of VS with deep learning, adapted to this data set. The applied neural network is based on the 2.5D UNet described in \"<a href=\"https:\/\/doi.org\/10.3171\/2019.9.jns191949\">An artificial intelligence framework for automatic segmentation and volumetry of vestibular schwannomas from contrast-enhanced T1-weighted and high-resolution T2-weighted MRI<\/a>\"<em> (<\/em>Shapey, et al., 2021<em>)<\/em>\u00a0and has been adapted to yield improved segmentation results. Our implementation uses MONAI, a freely available, PyTorch-based framework for deep learning in healthcare imaging (<a href=\"https:\/\/monai.io\/\">Project MONAI<\/a>). This new implementation was devised to provide a starting point for researchers interested in automatic segmentation using state-of-the art deep learning frameworks for medical image processing.\u00a0<\/p>\nAcknowledgements\nThis work was supported by Wellcome Trust (203145Z\/16\/Z, 203148\/Z\/16\/Z, WT106882), EPSRC (NS\/A000050\/1, NS\/A000049\/1) and MRC (MC_PC_180520)\u00a0funding. Tom Vercauteren is also\u00a0supported by a Medtronic\/Royal Academy of Engineering Research Chair (RCSRF1819\\7\\34).","collection_acknowledgements":"","collection_funding":"","hide_from_browse_table":[],"_links":{"self":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections\/5685"}],"collection":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections"}],"about":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/types\/tcia_collection"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media\/8200"}],"wp:attachment":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media?parent=5685"}],"wp:term":[{"taxonomy":"tcia_citation_tax","embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/v1\/citation-tax?post=5685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}