{"id":5682,"date":"2023-09-04T03:17:40","date_gmt":"2023-09-04T03:17:40","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/nsclc-cetuximab\/"},"modified":"2023-09-13T12:02:51","modified_gmt":"2023-09-13T12:02:51","slug":"nsclc-cetuximab","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/nsclc-cetuximab\/","title":{"rendered":"NSCLC-CETUXIMAB"},"featured_media":7669,"template":"","citation-tax":[],"cancer_types":["Non-small Cell Lung Cancer"],"citations":[4624,2925],"collection_doi":"http:\/\/doi.org\/10.7937\/TCIA.2018.jze75u7v","collection_download_info":"This is a\u00a0<u>limited access<\/u>\u00a0data set. To request access please register an account on the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0use the\u00a0\"Request Data\" link in the left side menu.\u00a0 Follow the on screen instructions, and enter\u00a0NCT00533949 when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a href=\"mailto:NCINCTNDataArchive@mail.nih.gov\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.\n\nClick the Versions tab for more info about data releases.\n<strong>Additional Resources for this Dataset<\/strong>\n<ul><li><strong><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/285\">Clinical Data on NCTN Data Archive<\/a><\/strong><\/li><\/ul>","collection_downloads":[5245],"full_export":"<h2 id=\"RTOG0617(NSCLCCetuximab)-Summary\">Summary<\/h2><p><span class=\"confluence-embedded-file-wrapper image-right-wrapper confluence-embedded-manual-size\"><img class=\"confluence-embedded-image image-right\" draggable=\"false\" width=\"413\" src=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/embedded-page\/Public\/RTOG-0617%20(NSCLC-Cetuximab)\/nctn%20logo.png?api=v2\"><\/span>This collection contains data from the National Cancer Insitute Clinical Trial <span style=\"color: rgb(0,0,0);\"><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00533949\" class=\"external-link\" rel=\"nofollow\">NCT00533949<\/a><span style=\"color: rgb(51,51,51);\">, &quot;High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery.&quot;\u00a0 It was sponsored by NCI's Radiation Therapy Oncology Group (RTOG)\u00a0under study number <a href=\"https:\/\/www.nrgoncology.org\/Clinical-Trials\/Protocol\/rtog-0617?filter=rtog-0617\" class=\"external-link\" rel=\"nofollow\">RTOG-0617<\/a>.\u00a0 Clinical data which <span style=\"color: rgb(73,73,73);\">will allow users to compare the adverse events and treatments between arms in trial<span>\u00a0are located on the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/285\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive<\/a>.\u00a0 Each patient's\u00a0<\/span><\/span>CT of the chest (including the adrenals) was obtained within 6 weeks of registration.<\/span><\/span><\/p><h3 id=\"RTOG0617(NSCLCCetuximab)-TrialDescription\"><span style=\"color: rgb(0,0,0);\"><span style=\"color: rgb(0,0,0);\">Trial Description<\/span><\/span><\/h3><p>Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.<\/p><h3 id=\"RTOG0617(NSCLCCetuximab)-TrialOutcomes\">Trial Outcomes\u00a0<\/h3><p>Results of the trial have been reported in the following publications:<\/p><ol><li><p>Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. <strong>Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial<\/strong>. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001\/jamaoncol.2015.3969. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4786463\/\" class=\"external-link\" rel=\"nofollow\">PMC4786463<\/a>)<\/p><\/li><li><p>Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. <strong>Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study<\/strong>. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016\/S1470-2045(14)71207-0. Epub 2015 Jan 16. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4419359\/\" class=\"external-link\" rel=\"nofollow\">PMC4419359<\/a>)<\/p><\/li><\/ol><p><br\/><\/p><div class=\"tab-style-builtin\"><div class=\"localtabs-macro\"><div class=\"aui-tabs horizontal-tabs\" role=\"application\" data-aui-responsive=\"true\"><ul class=\"tabs-menu\"><li class=\"menu-item bv-localtab  active-tab \"><a href=\"#33948334db2799c609dc4cd2a242293887d83e62\"><strong>Data Access<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#339483345d1db05cc1cf44d9a9ae643d14342a5e\"><strong>Detailed Description<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#33948334514766f39d5843a398e14fc3ec57ed93\"><strong>Citations &amp; Data Usage Policy<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#339483347c225c3bd1d8423091578a8521a1b7cb\"><strong>Versions<\/strong><\/a> <\/li><\/ul><div class=\"tabs-pane  active-pane \" id=\"33948334db2799c609dc4cd2a242293887d83e62\" active=\"true\" name=\"Data Access\" ><h3 id=\"RTOG0617(NSCLCCetuximab)-DataAccess\">Data Access<\/h3><p>This is a\u00a0<span style=\"color: rgb(255,0,0);\"><u>limited access<\/u><\/span>\u00a0data set. <span style=\"color: rgb(0,0,0);\">To request access please register an account on the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\" class=\"external-link\" rel=\"nofollow\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0<\/span><span style=\"color: rgb(0,0,0);\">use the\u00a0<\/span><span style=\"color: rgb(0,0,0);\">&quot;Request Data&quot; link in the left side menu.\u00a0 Follow the on screen instructions, and enter\u00a0<\/span><span style=\"color: rgb(0,0,0);\">NCT00533949 when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a href=\"mailto:NCINCTNDataArchive@mail.nih.gov\" class=\"external-link\" rel=\"nofollow\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.<\/span><\/p><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 64.1447%;\"><colgroup><col style=\"width: 36.0329%;\"\/><col style=\"width: 39.6638%;\"\/><col style=\"width: 24.262%;\"\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\">Images\u00a0a<span style=\"color: rgb(38,44,49);\">nd Radiation Therapy Structures<\/span> ( 42.7GB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/33948334\/NSCLC-Cetuximab-NBIA-manifest-1542748233353.tcia?version=1&amp;modificationDate=1542748333870&amp;api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=NSCLC-Cetuximab\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p>(Download requires\u00a0the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" rel=\"nofollow\">NBIA Data Retriever<\/a>)<\/p><p><br\/><\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p><span class=\"confluence-link\">\n<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/sites\/default\/files\/DUA\/NCTN_NCORP_Data_Archive_DUA_CA_v2019-06-12.pdf?version=1&amp;modificationDate=1652964581655&amp;api=v2\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive License (With Collaborative Agreement)<\/a><br\/><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p>Click the Versions tab for more info about data releases.<\/p><p><strong>Additional Resources for this Dataset<\/strong><\/p><ul><li><strong><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/285\" class=\"external-link\" rel=\"nofollow\">Clinical Data on NCTN Data Archive<\/a><\/strong><\/li><\/ul><\/div><div class=\"tabs-pane \" id=\"339483345d1db05cc1cf44d9a9ae643d14342a5e\" name=\"Detailed Description\" ><h3 id=\"RTOG0617(NSCLCCetuximab)-DetailedDescription\">Detailed Description<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><p>Collection Statistics<\/p><\/div><\/th><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><p><br\/><\/p><\/div><\/th><\/tr><tr><td class=\"confluenceTd\"><p>Modalities<\/p><\/td><td class=\"confluenceTd\"><p>CT, RTSTRUCT, RTDOSE, RTPLAN<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Participants<\/p><\/td><td class=\"confluenceTd\"><p>490<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Studies<\/p><\/td><td class=\"confluenceTd\"><p>490<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Series<\/p><\/td><td class=\"confluenceTd\"><p>2116<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Images<\/p><\/td><td class=\"confluenceTd\"><p>75063<\/p><\/td><\/tr><tr><td colspan=\"1\" class=\"confluenceTd\">Image Size (GB)<\/td><td colspan=\"1\" class=\"confluenceTd\">42.7<\/td><\/tr><\/tbody><\/table><\/div><p class=\"auto-cursor-target\"><h2 id=\"RTOG0617(NSCLCCetuximab)-De-identificationofDICOMdates\">De-identification of DICOM dates<\/h2><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0<span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/span><\/span><\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the &quot;Days from registration&quot; would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h2 id=\"RTOG0617(NSCLCCetuximab)-Insertionofcomputed&quot;REGISTRATION&quot;\/Daysoffsetfromregistration&quot;value\">Insertion of computed &quot;REGISTRATION&quot;\/Days offset from registration&quot; value<\/h2><p style=\"text-align: left;\">In addition to modifying the actual date fields in the DICOM header, the &quot;days from registration&quot; values are calculated and stored in the DICOM tag<strong> (0012,0052) <span style=\"color: rgb(34,34,34);\">Longitudinal Temporal Offset from Event<\/span><\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p style=\"text-align: left;\"><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p><p><br\/><\/p><\/p><\/div><div class=\"tabs-pane \" id=\"33948334514766f39d5843a398e14fc3ec57ed93\" name=\"Citations BITVOODOO_ANDamp; Data Usage Policy\" ><h3 id=\"RTOG0617(NSCLCCetuximab)-Citations&amp;DataUsagePolicy\">Citations &amp; Data Usage Policy\u00a0<\/h3><p>\n<p>\nUsers must abide by the <a href=\"https:\/\/wiki.cancerimagingarchive.net\/x\/c4hF\" class=\"external-link\" rel=\"nofollow\">TCIA Data Usage Policy and Restrictions<\/a>. Attribution should include references to the following citations:\n<\/p><\/p><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Data Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span>Bradley, J.; <\/span><span>Forster, K.<\/span> (2018). <strong>Data from NSCLC-Cetuximab<\/strong>. The Cancer Imaging Archive. DOI:\u00a0<a href=\"http:\/\/doi.org\/10.7937\/TCIA.2018.jze75u7v\" class=\"external-link\" rel=\"nofollow\">http:\/\/doi.org\/10.7937\/TCIA.2018.jze75u7v<\/a><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">TCIA Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p>Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F.\u00a0<strong>The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository<\/strong>, Journal of Digital Imaging, Volume 26, Number 6, December, 2013, pp 1045-1057. DOI:\u00a0<span style=\"color: rgb(51,51,51);\"><a href=\"https:\/\/doi.org\/10.1007\/s10278-013-9622-7\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s10278-013-9622-7<\/a><\/span><\/p><\/div><\/div><h3 id=\"RTOG0617(NSCLCCetuximab)-AdditionalPublicationResources:\">Additional Publication Resources:<\/h3><p>The Collection authors suggest the below will give context to this dataset:<\/p><ul><li><p>Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. <strong>Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial<\/strong>. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001\/jamaoncol.2015.3969. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4786463\/\" class=\"external-link\" rel=\"nofollow\">PMC4786463<\/a>)<\/p><\/li><li><p>Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. <strong>Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study<\/strong>. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016\/S1470-2045(14)71207-0. Epub 2015 Jan 16. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4419359\/\" class=\"external-link\" rel=\"nofollow\">PMC4419359<\/a>)<\/p><\/li><\/ul><h3 id=\"RTOG0617(NSCLCCetuximab)-OtherPublicationsUsingThisData\">Other Publications Using This Data<\/h3><p><span><span>See the <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\" class=\"external-link\" rel=\"nofollow\"> TCIA Publications page<\/a>\u00a0<\/span><span>for other work leveraging this collection.<\/span>\u00a0<\/span><span>If you have a publication you'd like to add please<\/span><a rel=\"nofollow\" href=\"http:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\">\u00a0contact the TCIA Helpdesk<\/a><span>.<\/span><\/p><\/div><div class=\"tabs-pane \" id=\"339483347c225c3bd1d8423091578a8521a1b7cb\" name=\"Versions\" ><h3 id=\"RTOG0617(NSCLCCetuximab)-Version1(Current):Updated2019\/04\/15\">Version 1 (Current): Updated 2019\/04\/15<\/h3><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 33.4253%;\"><colgroup><col style=\"width: 44.3215%;\"\/><col style=\"width: 55.6573%;\"\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><\/tr><tr><td class=\"confluenceTd\">Images ( 42.7GB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/33948334\/NSCLC-Cetuximab-NBIA-manifest-1542748233353.tcia?version=1&amp;modificationDate=1542748333870&amp;api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=NSCLC-Cetuximab\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p>(Download requires\u00a0the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" rel=\"nofollow\">NBIA Data Retriever<\/a>)<\/p><p><span class=\"confluence-link\"><br\/><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p><br\/><\/p><\/div><\/div><\/div><\/div>","versions":false,"additional_resources":"","cancer_locations":["Lung"],"collection_page_accessibility":"Public","publications_related":"","version_change_log":"","version_change_log_archived":"","analysis_results":"","collection_status":"Complete","publications_using":"See the <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\"> TCIA Publications page<\/a>\u00a0for other work leveraging this collection.\u00a0If you have a publication you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\">\u00a0contact the TCIA Helpdesk<\/a>.","species":["Human"],"collection_title":"RTOG-0617","detailed_description":"<h3>De-identification of DICOM dates<\/h3><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the \"Days from registration\" would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h3>Insertion of computed \"REGISTRATION\"\/Days offset from registration\" value<\/h3><p>In addition to modifying the actual date fields in the DICOM header, the \"days from registration\" values are calculated and stored in the DICOM tag<strong> (0012,0052) Longitudinal Temporal Offset from Event<\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p>","related_analysis_results":false,"subjects":"490","collection_short_title":"NSCLC-Cetuximab","data_types":["CT","RTSTRUCT","RTDOSE","RTPLAN"],"date_updated":"2023-09-13","collection_browse_title":"","supporting_data":["Clinical"],"collection_featured_image":{"ID":"7669","post_author":"6","post_date":"2023-09-13 03:38:25","post_date_gmt":"2023-09-13 03:38:25","post_content":"","post_title":"nctn-logo","post_excerpt":"","post_status":"inherit","comment_status":"open","ping_status":"closed","post_password":"","post_name":"nctn-logo","to_ping":"","pinged":"","post_modified":"2023-09-13 11:56:51","post_modified_gmt":"2023-09-13 11:56:51","post_content_filtered":"","post_parent":"5551","guid":"https:\/\/cm.vastapps.dev\/wp-content\/uploads\/nctn-logo.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"7669"},"collection_summary":"This collection contains data from the National Cancer Insitute Clinical Trial <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00533949\">NCT00533949<\/a>, \"High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery.\"\u00a0 It was sponsored by NCI's Radiation Therapy Oncology Group (RTOG)\u00a0under study number <a href=\"https:\/\/www.nrgoncology.org\/Clinical-Trials\/Protocol\/rtog-0617?filter=rtog-0617\">RTOG-0617<\/a>.\u00a0 Clinical data which will allow users to compare the adverse events and treatments between arms in trial\u00a0are located on the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/285\">NCTN\/NCORP Data Archive<\/a>.\u00a0 Each patient's\u00a0CT of the chest (including the adrenals) was obtained within 6 weeks of registration.\n<h3>Trial Description<\/h3>\nRadiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.\n<h3>Trial Outcomes\u00a0<\/h3>\nResults of the trial have been reported in the following publications:\n<ol><li><p>Movsas B, Hu C, Sloan J, Bradley J, Komaki R, Masters G, Kavadi V, Narayan S, Michalski J, Johnson DW, Koprowski C, Curran WJ Jr, Garces YI, Gaur R, Wynn RB, Schallenkamp J, Gelblum DY, MacRae RM, Paulus R, Choy H. <strong>Quality of Life Analysis of a Radiation Dose-Escalation Study of Patients With Non-Small-Cell Lung Cancer: A Secondary Analysis of the Radiation Therapy Oncology Group 0617 Randomized Clinical Trial<\/strong>. JAMA Oncol. 2016 Mar;2(3):359-67. doi: 10.1001\/jamaoncol.2015.3969. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4786463\/\">PMC4786463<\/a>)<\/p><\/li><li><p>Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H. <strong>Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study<\/strong>. Lancet Oncol. 2015 Feb;16(2):187-99. doi: 10.1016\/S1470-2045(14)71207-0. Epub 2015 Jan 16. (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc4419359\/\">PMC4419359<\/a>)<\/p><\/li><\/ol>\n<br\/>","collection_acknowledgements":"","collection_funding":"","hide_from_browse_table":[],"_links":{"self":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections\/5682"}],"collection":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections"}],"about":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/types\/tcia_collection"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media\/7669"}],"wp:attachment":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media?parent=5682"}],"wp:term":[{"taxonomy":"tcia_citation_tax","embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/v1\/citation-tax?post=5682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}