DCE\u2010MRI:<\/strong> <\/u>\u00a0All 19 patients had repeat dynamic contrast\u2010enhanced MRI (DCE\u2010MRI) datasets on the same 1.5T imaging magnet.\u00a0\u00a0On the basis of T2\u2010weighted images, technologists chose 16 image locations using 5mm thick contiguous slices for the imaging.\u00a0\u00a0For T1 mapping, multi\u2010flip 3D FLASH images were obtained using flip angles of 5, 10, 15, 20, 25 and 30 degrees, TR of 4.43 ms, TE of 2.1 ms, 2 signal averages.\u00a0\u00a0Dynamic images were obtained during the intravenous injection of 0.1mmol\/kg of Magnevist intravenous at 3ccs\/second, started 24 seconds after the scan had begun.\u00a0\u00a0The dynamic images were acquired using a 3D FLASH technique, using a flip angle of 25 degrees, TR of 3.8 ms, TE of 1.8 ms using a 1 x1 x 5mm voxel size.\u00a0\u00a0The 16 slice imaging set was obtained every 4.8 sec.<\/p> DTI:<\/strong><\/u> Seventeen of the 19 patients also obtained repeat diffusion tensor imaging (DTI) sets.\u00a0\u00a0Whole brain DTI were obtained using TR 6000ms, TE 100 ms, 90 degree flip angle, 4 signal averages, matrix 128 x 128,\u00a0\u00a01.72 x 1.72 x 5 mm voxel size, 12 tensor directions, iPAT 2, b value of 1000 sec\/mm2 .<\/p> Contrast\u2010enhanced 3D FLASH:<\/strong><\/u> All 19 patients underwent whole brain 3D FLASH imaging in the sagittal plane after the administration of Magnevist.\u00a0\u00a0For this sequence, TR was 8.6 ms, TE 4.1 ms, 20 degree flip angle, 1 signal average, matrix 256 x 256; 1mm isotropic\u00a0\u00a0voxel\u00a0\u00a0size.<\/p> Contrast\u2010enhanced 3D FLAIR:<\/strong><\/u> All 17 patients who had repeat DTI sets also had 3D FLAIR sequences in the sagittal plane after the administration of Magnevist.\u00a0\u00a0For this sequence, the TR was 6000 ms, TE 353 ms, and TI 2200ms; 180 degree flip angle, 1 signal average, matrix 256 x 216; 1 mm isotropic voxel size. Note: before transmission to NCIA, all image sets with 1mm isotropic voxel size were \u201cdefaced\u201d using MIPAV software or manually.<\/p> The Reference Image Database to Evaluate Therapy Response (RIDER) is a targeted data collection used to generate an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods applied to measure the response to drug or radiation therapy. \u00a0The National Cancer Institute (NCI) has exercised a series of contracts with specific academic sites for collection of repeat "coffee break," longitudinal phantom, and patient data for a range of imaging modalities (currently computed tomography [CT]\u00a0positron emission tomography [PET]\u00a0CT, dynamic contrast-enhanced magnetic resonance imaging [DCE MRI], diffusion-weighted [DW] MRI) and organ sites (currently lung, breast, and neuro). <\/span>The methods for data collection, analysis, and results are described in the new Combined RIDER White Paper Report (Sept 2008):<\/p>