{"id":5669,"date":"2023-09-04T03:16:45","date_gmt":"2023-09-04T03:16:45","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/arar0331\/"},"modified":"2023-09-13T12:02:21","modified_gmt":"2023-09-13T12:02:21","slug":"arar0331","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/arar0331\/","title":{"rendered":"ARAR0331"},"featured_media":7669,"template":"","citation-tax":[],"cancer_types":["Nasopharyngeal"],"citations":[4606,4607,2925],"collection_doi":"10.7937\/WTEC-MN22","collection_download_info":"This is a\u00a0<strong><u>limited access<\/u><\/strong>\u00a0data set.\u00a0To request access please register an account on the\u00a0<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0use the\u00a0\"Request Data\" link in the left side menu.\u00a0 Follow the on screen instructions, and enter \u00a0<strong>NCT00274937<\/strong>\u00a0when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a href=\"mailto:NCINCTNDataArchive@mail.nih.gov\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.\n\nClick the Versions tab for more info about data releases.","collection_downloads":[5219],"full_export":"<h1 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-Summary\">Summary<\/h1><p><span style=\"color: rgb(0,0,0);\"><span class=\"confluence-embedded-file-wrapper image-right-wrapper confluence-embedded-manual-size\"><img class=\"confluence-embedded-image image-right\" draggable=\"false\" width=\"417\" src=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/embedded-page\/Public\/Radiation%20Therapy,%20Amifostine,%20and%20Chemotherapy%20in%20Treating%20Young%20Patients%20With%20Newly%20Diagnosed%20Nasopharyngeal%20Cancer%20(ARAR0331)\/nctn%20logo.png?api=v2\"><\/span><\/span><\/p><p>This collection contains data from the Children\u2019s Oncology Group (COG) Clinical Trial <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00274937\" class=\"external-link\" rel=\"nofollow\">NCT00274937<\/a>, \u201cRadiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer&quot;. Principal Investigator: Carlos Rodriguez-Galindo, MD.\u00a0 It was sponsored by NCI and performed by the Children's Oncology Group under study number ARAR0331. This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells. Select patient-level data from this trial is available via the following link: <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302\" class=\"external-link\" rel=\"nofollow\">https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302<\/a>. \u00a0<\/p><p><strong>Trial Outcomes <\/strong><\/p><p>Results of the trial have been reported in the following publications:<\/p><ul><li>Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH. Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16. J Clin Oncol. 2019 Dec 10;37(35):3377-3391. doi: <a href=\"https:\/\/doi.org\/10.1200\/jco.19.01692\" class=\"external-link\" rel=\"nofollow\">10.1200\/JCO.19.01692<\/a>. Epub 2019 Oct 28.<\/li><li>Rodriguez-Galindo C, Krailo MD, Krasin MJ, Huang L, McCarville MB, Hicks J, Pashankar F, Pappo AS. Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study. J Clin Oncol. 2019 Dec 10;37(35):3369-3376. doi: <span class=\"identifier doi\"><a class=\"external-link\" href=\"https:\/\/doi.org\/10.1200\/jco.19.01276\" style=\"text-decoration: none;\" rel=\"nofollow\">10.1200\/JCO.19.01276<\/a><\/span>. Epub 2019 Sep 25. Erratum in: J Clin Oncol. 2021 May 10;39(14):1602.<\/li><\/ul><p><br\/><br\/><\/p><div class=\"tab-style-builtin\"><div class=\"localtabs-macro\"><div class=\"aui-tabs horizontal-tabs\" role=\"application\" data-aui-responsive=\"true\"><ul class=\"tabs-menu\"><li class=\"menu-item bv-localtab  active-tab \"><a href=\"#12560009017a94788d6f94013b21ec5b30448fd5b\"><strong>Data Access<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#12560009067e8dad4875146dab82241d12e610fff\"><strong>Detailed Description<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#1256000908a6c7524732b425a8fffebd8c8372e80\"><strong>Citations &amp; Data Usage Policy<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#12560009050fdf94e2bac4e098a87b81d4aa1f046\"><strong>Versions<\/strong><\/a> <\/li><\/ul><div class=\"tabs-pane  active-pane \" id=\"12560009017a94788d6f94013b21ec5b30448fd5b\" active=\"true\" name=\"Data Access\" ><h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-DataAccess\">Data Access<\/h3><p><span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(33,37,41);\">This is a\u00a0<\/span><strong><u>limited access<\/u><\/strong><span style=\"color: rgb(33,37,41);\">\u00a0data set.\u00a0<\/span><span style=\"color: rgb(0,0,0);\">To request access please register an account on the\u00a0<a class=\"external-link\" href=\"https:\/\/nctn-data-archive.nci.nih.gov\/\" rel=\"nofollow\" style=\"text-decoration: none;\">NCTN Data Archive<\/a>.\u00a0 After logging in,\u00a0<\/span><span style=\"color: rgb(0,0,0);\">use the\u00a0<\/span><span style=\"color: rgb(0,0,0);\">&quot;Request Data&quot; link in the left side menu.\u00a0 Follow the on screen instructions, and enter <span>\u00a0<\/span><strong>NCT00274937<\/strong><\/span><span style=\"color: rgb(0,0,0);\">\u00a0when asked which trial you want to request.\u00a0\u00a0In step 2 of the Create Request form, be sure to select \u201cImaging Data Requested\u201d. Please contact\u00a0<a rel=\"nofollow\" style=\"text-decoration: none;\" href=\"mailto:NCINCTNDataArchive@mail.nih.gov\" class=\"external-link\">NCINCTNDataArchive@mail.nih.gov<\/a>\u00a0for any questions about access requests.<\/span><\/span><\/p><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Images (DICOM, 119 GB)<\/p><p><br\/><\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/125600090\/ARAR0331%20manifest%20September%202022.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=ARAR0331\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p><span style=\"color: rgb(33,37,41);text-decoration: none;\">(Download requires\u00a0<\/span><span style=\"color: rgb(33,37,41);text-decoration: none;\">the<span>\u00a0<\/span><\/span><a style=\"text-decoration: none;text-align: left;\" rel=\"nofollow\" href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/sites\/default\/files\/DUA\/NCTN_NCORP_Data_Archive_DUA_CA_v2019-06-12.pdf?version=1&amp;modificationDate=1652964581655&amp;api=v2\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive License (Without Collaborative Agreement)<\/a><\/p><p><br\/><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p>Click the Versions tab for more info about data releases.<\/p><p>\n<h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-AdditionalResourcesforthisDataset\">Additional Resources for this Dataset<\/h3>\n<p>The National Cancer Institute (NCI) has created a centralized, controlled-access database, called the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/about-us\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive<\/a>, for storing and sharing datasets generated from clinical trials of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP).  Clinical data from the participants in this trial can be found at:\n<\/p><\/p><ul><li><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302\" class=\"external-link\" rel=\"nofollow\">NCTN\/NCORP Data Archive<\/a><span>\u00a0<\/span>(Clinical Data)<\/li><\/ul><\/div><div class=\"tabs-pane \" id=\"12560009067e8dad4875146dab82241d12e610fff\" name=\"Detailed Description\" ><h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-DetailedDescription\">Detailed Description<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\"><p>Image Statistics<\/p><\/th><th class=\"confluenceTh\">Radiology Image Statistics<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Modalities<\/p><\/td><td class=\"confluenceTd\"><p>CT, MR ,NM ,PT ,RTIMAGE<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Patients<\/p><\/td><td class=\"confluenceTd\"><p>108<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Studies<\/p><\/td><td class=\"confluenceTd\"><p>803<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Series<\/p><\/td><td class=\"confluenceTd\"><p>7010<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Images<\/p><\/td><td class=\"confluenceTd\"><p>330052<\/p><\/td><\/tr><tr><td class=\"confluenceTd\">Images Size (GB)<\/td><td class=\"confluenceTd\">119<\/td><\/tr><\/tbody><\/table><\/div><p><br\/><\/p><p><h2 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-De-identificationofDICOMdates\">De-identification of DICOM dates<\/h2><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0<span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/span><\/span><\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the &quot;Days from registration&quot; would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h2 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-Insertionofcomputed&quot;REGISTRATION&quot;\/Daysoffsetfromregistration&quot;value\">Insertion of computed &quot;REGISTRATION&quot;\/Days offset from registration&quot; value<\/h2><p style=\"text-align: left;\">In addition to modifying the actual date fields in the DICOM header, the &quot;days from registration&quot; values are calculated and stored in the DICOM tag<strong> (0012,0052) <span style=\"color: rgb(34,34,34);\">Longitudinal Temporal Offset from Event<\/span><\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p style=\"text-align: left;\"><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p><p><br\/><\/p><\/p><\/div><div class=\"tabs-pane \" id=\"1256000908a6c7524732b425a8fffebd8c8372e80\" name=\"Citations BITVOODOO_ANDamp; Data Usage Policy\" ><h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-Citations&amp;DataUsagePolicy\">Citations &amp; Data Usage Policy<\/h3><p>\n<p>\nUsers must abide by the <a href=\"https:\/\/wiki.cancerimagingarchive.net\/x\/c4hF\" class=\"external-link\" rel=\"nofollow\">TCIA Data Usage Policy and Restrictions<\/a>. Attribution should include references to the following citations:\n<\/p><\/p><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Data Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Rodriguez-Galindo, C., Krailo, M. D., Krasin, M. J., Huang, L., McCarville, M. B., Hicks, J., Pashankar, F., &amp; Pappo, A. S. (2022). Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer (ARAR0331) (Version 1) [Data set]. The Cancer Imaging Archive.<\/span> <a href=\"https:\/\/doi.org\/10.7937\/WTEC-MN22\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.7937\/WTEC-MN22<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Publication Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span class=\"identifier pmc\"><span class=\"id-label\"><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Rodriguez-Galindo, C., Krailo, M. D., Krasin, M. J., Huang, L., McCarville, M. B., Hicks, J., Pashankar, F., &amp; Pappo, A. S. (2019). Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children\u2019s Oncology Group ARAR0331 Study. In Journal of Clinical Oncology (Vol. 37, Issue 35, pp. 3369\u20133376). American Society of Clinical Oncology (ASCO).<\/span> <a href=\"https:\/\/doi.org\/10.1200\/jco.19.01276\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1200\/jco.19.01276<\/a>. <\/span>PMCID:<span>\u00a0<\/span><\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6920031\/\" style=\"text-decoration: none;\" class=\"external-link\" rel=\"nofollow\">PMC6920031<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">TCIA Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p class=\"p1\">Clark, K., Vendt, B., Smith, K., Freymann, J., Kirby, J., Koppel, P., Moore, S., Phillips, S., Maffitt, D., Pringle, M., Tarbox, L., &amp; Prior, F. (2013). The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository. In Journal of Digital Imaging (Vol. 26, Issue 6, pp. 1045\u20131057). Springer Science and Business Media LLC. <a href=\"https:\/\/doi.org\/10.1007\/s10278-013-9622-7\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s10278-013-9622-7<\/a><\/p><\/div><\/div><h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-OtherPublicationsUsingThisData\">Other Publications Using This Data<\/h3><p><span>TCIA maintains\u00a0<\/span><a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\" class=\"external-link\" rel=\"nofollow\">a list of publications<\/a><span> which leverage TCIA data. <\/span> If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\" rel=\"nofollow\"> contact the TCIA Helpdesk<\/a>.<\/p><\/div><div class=\"tabs-pane \" id=\"12560009050fdf94e2bac4e098a87b81d4aa1f046\" name=\"Versions\" ><h3 id=\"RadiationTherapy,Amifostine,andChemotherapyinTreatingYoungPatientsWithNewlyDiagnosedNasopharyngealCancer(ARAR0331)-Version1(Current):Updated2022\/10\/21\">Version 1 (Current): Updated 2022\/10\/21<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><colgroup><col\/><col\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><\/tr><tr><td class=\"confluenceTd\"><p>Images (DICOM, 119 GB)<\/p><p><br\/><\/p><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/125600090\/ARAR0331%20manifest%20September%202022.tcia?api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/nbia.cancerimagingarchive.net\/nbia-search\/?MinNumberOfStudiesCriteria=1&amp;CollectionCriteria=ARAR0331\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p><span style=\"color: rgb(33,37,41);text-decoration: none;\">(Download requires\u00a0<\/span><span style=\"color: rgb(33,37,41);text-decoration: none;\">the<span>\u00a0<\/span><\/span><a rel=\"nofollow\" style=\"text-decoration: none;text-align: left;\" href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><\/div><\/div><p><br\/><\/p><p><br\/><\/p>","versions":false,"additional_resources":"The National Cancer Institute (NCI) has created a centralized, controlled-access database, called the <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/about-us\">NCTN\/NCORP Data Archive<\/a>, for storing and sharing datasets generated from clinical trials of the National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP).  Clinical data from the participants in this trial can be found at:\n\n \n<ul><li><a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302\">NCTN\/NCORP Data Archive<\/a>\u00a0(Clinical Data)<\/li><\/ul>","cancer_locations":["Head"],"collection_page_accessibility":"Public","publications_related":"","version_change_log":"","version_change_log_archived":"","analysis_results":"","collection_status":"Complete","publications_using":"TCIA maintains\u00a0<a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> which leverage TCIA data.  If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\"> contact the TCIA Helpdesk<\/a>.","species":["Human"],"collection_title":"Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer","detailed_description":"<br\/>\n<h3>De-identification of DICOM dates<\/h3><p>De-identification of dates for this dataset uses the DICOM Part 3.15 Annex E standard \u201cRetain Longitudinal With Modified Dates Option\u201d which allows dates to be retained as long as they are modified from the original date.\u00a0 TCIA implements this using a technique which de-identifies the dates while preserving the longitudinal relationship between them. \u00a0Original dates will be first normalized to 01 January, 1960 and then offset relative to the date of registration for each patient.\u00a0 This normalized date system was chosen in order to make it obvious that the dates are not real, and to make it easy to quickly determine how much time has passed between the date of registration and the patients' related imaging studies.\u00a0 <\/p><p>For example, if the real date of a patient's registration was 03\/27\/2018 and the original imaging Study Date was 03\/29\/2018 then the \"Days from registration\" would be +2 and the anonymized TCIA Study Date would become 01\/03\/1960.<\/p><h3>Insertion of computed \"REGISTRATION\"\/Days offset from registration\" value<\/h3><p>In addition to modifying the actual date fields in the DICOM header, the \"days from registration\" values are calculated and stored in the DICOM tag<strong> (0012,0052) Longitudinal Temporal Offset from Event<\/strong> with the associated tag <strong>(0012,0053) Longitudinal Temporal Event Type<\/strong> set to \u201cREGISTRATION\u201d.\u00a0<\/p><p><u><strong>Note:<\/strong><\/u> If these DICOM tags are not present, DICOM tag <strong>(0012,0050) Clinical Trial Time Point ID<\/strong> with the associated tag <strong>(0012,0051) Clinical Trial Time Point Description<\/strong> provides this same information.\u00a0 This inconsistency is due to a change in how dates were handled in the first NCTN trials that were published on TCIA.<\/p>","related_analysis_results":false,"subjects":"108","collection_short_title":"ARAR0331","data_types":["CT","MR","NM","PT","RTIMAGE"],"date_updated":"2023-09-13","collection_browse_title":"","supporting_data":["Clinical"],"collection_featured_image":{"ID":"7669","post_author":"6","post_date":"2023-09-13 03:38:25","post_date_gmt":"2023-09-13 03:38:25","post_content":"","post_title":"nctn-logo","post_excerpt":"","post_status":"inherit","comment_status":"open","ping_status":"closed","post_password":"","post_name":"nctn-logo","to_ping":"","pinged":"","post_modified":"2023-09-13 11:56:51","post_modified_gmt":"2023-09-13 11:56:51","post_content_filtered":"","post_parent":"5551","guid":"https:\/\/cm.vastapps.dev\/wp-content\/uploads\/nctn-logo.png","menu_order":"0","post_type":"attachment","post_mime_type":"image\/png","comment_count":"0","pod_item_id":"7669"},"collection_summary":"<p>This collection contains data from the Children\u2019s Oncology Group (COG) Clinical Trial <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00274937\">NCT00274937<\/a>, \u201cRadiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer\". Principal Investigator: Carlos Rodriguez-Galindo, MD.\u00a0 It was sponsored by NCI and performed by the Children's Oncology Group under study number ARAR0331. This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells. Select patient-level data from this trial is available via the following link: <a href=\"https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302\">https:\/\/nctn-data-archive.nci.nih.gov\/node\/1302<\/a>. \u00a0<\/p><p><strong>Trial Outcomes <\/strong><\/p><p>Results of the trial have been reported in the following publications:<\/p><ul><li>Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH. Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16. J Clin Oncol. 2019 Dec 10;37(35):3377-3391. doi: <a href=\"https:\/\/doi.org\/10.1200\/jco.19.01692\">10.1200\/JCO.19.01692<\/a>. Epub 2019 Oct 28.<\/li><li>Rodriguez-Galindo C, Krailo MD, Krasin MJ, Huang L, McCarville MB, Hicks J, Pashankar F, Pappo AS. Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study. J Clin Oncol. 2019 Dec 10;37(35):3369-3376. doi: <a href=\"https:\/\/doi.org\/10.1200\/jco.19.01276\">10.1200\/JCO.19.01276<\/a>. Epub 2019 Sep 25. Erratum in: J Clin Oncol. 2021 May 10;39(14):1602.<\/li><\/ul>\n<br\/><br\/>","collection_acknowledgements":"","collection_funding":"","hide_from_browse_table":[],"_links":{"self":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections\/5669"}],"collection":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections"}],"about":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/types\/tcia_collection"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media\/7669"}],"wp:attachment":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media?parent=5669"}],"wp:term":[{"taxonomy":"tcia_citation_tax","embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/v1\/citation-tax?post=5669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}