{"id":5630,"date":"2023-09-04T03:13:53","date_gmt":"2023-09-04T03:13:53","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-collection\/mouse-mammary\/"},"modified":"2023-09-13T12:00:36","modified_gmt":"2023-09-13T12:00:36","slug":"mouse-mammary","status":"publish","type":"tcia_collection","link":"https:\/\/cm.vastapps.dev\/tcia-collection\/mouse-mammary\/","title":{"rendered":"MOUSE-MAMMARY"},"featured_media":0,"template":"","citation-tax":[],"cancer_types":["Breast Cancer"],"citations":[4535,2925],"collection_doi":"10.7937\/K9\/TCIA.2015.9P42KSE6","collection_download_info":"Click the Versions tab for more info about data releases.","collection_downloads":[5127],"full_export":"<div class=\"contentLayout2\">\n<div class=\"columnLayout two-right-sidebar\" data-layout=\"two-right-sidebar\">\n<div class=\"cell normal\" data-type=\"normal\">\n<div class=\"innerCell\">\n<h2 id=\"MouseMammary-Summary\">Summary<\/h2><span>This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of breast cancer.\u00a0 These images were acquired as part of a Department of Defense (DOD) Breast Cancer Research Program (BCRP) Postdoctoral Award W81XWH-12-1-0307 entitled \u201c<\/span><em>Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse Models<\/em><p><span style=\"line-height: 1.4285715;\">A particular emphasis of this project was to study the earliest stages of breast cancer\u2014preinvasive ductal carcinoma <\/span><em style=\"line-height: 1.4285715;\">in situ <\/em><span style=\"line-height: 1.4285715;\">(DCIS)\u2014and to interrogate the underlying genetic events that influence progression into invasive disease. In particular, we focused on the role of perturbed Rb, p53 and BRCA1 functionality and how these pathways, acting alone and in combination, can influence the development and progression of DCIS. GEMMs serve as an excellent model system wherein genetic changes can be controlled and manipulated over time.\u00a0 <\/span><em style=\"line-height: 1.4285715;\">In vivo<\/em><span style=\"line-height: 1.4285715;\"> MRI is a superb technique for noninvasively tracking and characterizing these microscopic early stage cancers as they develop, change and transition into lethal invasive disease.<\/span><\/p><p>For scientific or other inquiries about this dataset, please <a href=\"https:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\" rel=\"nofollow\">contact TCIA's Helpdesk<\/a>.<\/p><h3 id=\"MouseMammary-Acknowledgements\">Acknowledgements<\/h3><p><strong style=\"font-size: 16.0px;line-height: 1.5;\"><span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">\u00a0<\/span><\/span><\/strong>We would like to acknowledge the individuals and institutions that have provided data for this collection:<\/p><ul><li><strong style=\"font-size: 16.0px;line-height: 1.5;\"><span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">\u00a0<\/span><\/span><\/strong><span style=\"color: rgb(0,0,0);\"><strong>National Cancer Institute (Frederick, Maryland) -\u00a0<\/strong>Special thanks to<strong>\u00a0Sunny Jansen, PhD<\/strong>\u00a0 from the Department of\u00a0<\/span><span style=\"color: rgb(0,0,0);\"><strong>Mouse Cancer Genetics Program.<\/strong><\/span><\/li><\/ul><p><span style=\"color: rgb(0,0,0);\"><strong><br\/><\/strong><\/span><\/p><div class=\"tab-style-builtin\"><div class=\"localtabs-macro\"><div class=\"aui-tabs horizontal-tabs\" role=\"application\" data-aui-responsive=\"true\"><ul class=\"tabs-menu\"><li class=\"menu-item bv-localtab  active-tab \"><a href=\"#20644280bebfcb9ba0c74b728c3439c3b7026e44\"><strong>Data Access<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#20644280a04aa770ec494b81b4a99f154f509101\"><strong>Detailed Description<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#206442805e4347f12179400fa1daf8a7a7c383a9\"><strong>Citations &amp; Data Usage Policy<\/strong><\/a> <\/li><li class=\"menu-item bv-localtab \"><a href=\"#20644280a4c274a1b9d94137bf6ffd5a54f4a0f3\"><strong>Versions<\/strong><\/a> <\/li><\/ul><div class=\"tabs-pane  active-pane \" id=\"20644280bebfcb9ba0c74b728c3439c3b7026e44\" active=\"true\" name=\"Data Access\" ><h3 id=\"MouseMammary-DataAccess\">Data Access<\/h3><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 60.1923%;\"><colgroup><col style=\"width: 23.704%;\"\/><col style=\"width: 43.1335%;\"\/><col style=\"width: 33.1559%;\"\/><\/colgroup><tbody><tr><th class=\"confluenceTh\">Data Type<\/th><th class=\"confluenceTh\">Download all or Query\/Filter<\/th><th class=\"confluenceTh\">License<\/th><\/tr><tr><td class=\"confluenceTd\">Images (DICOM, 8.6GB)<\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/20644280\/TCIA_Mouse-Mammary_06-22-2015.tcia?version=1&amp;modificationDate=1534787010965&amp;api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/www.cancerimagingarchive.net\/nbia-search\/?CollectionCriteria=Mouse-mammary\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p>(Download requires\u00a0the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" rel=\"nofollow\">NBIA Data Retriever<\/a>)<\/p><\/div><\/td><td class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n<a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/\" class=\"external-link\" rel=\"nofollow\">CC BY 3.0<\/a><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><p>Click the Versions tab for more info about data releases.<\/p><p>\n<h3 id=\"MouseMammary-AdditionalResourcesforthisDataset\">Additional Resources for this Dataset<\/h3>\n<p>The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.<\/p><\/p><ul><li class=\"auto-cursor-target\"><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=mouse_mammary\" class=\"external-link\" rel=\"nofollow\">Imaging Data Commons (IDC)<\/a> (Imaging Data)<\/li><\/ul><\/div><div class=\"tabs-pane \" id=\"20644280a04aa770ec494b81b4a99f154f509101\" name=\"Detailed Description\" ><h3 id=\"MouseMammary-DetailedDescription\">Detailed Description<\/h3><div class=\"table-wrap\"><table class=\"wrapped confluenceTable\"><tbody><tr><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><p>Collection Statistics<\/p><\/div><\/th><th class=\"confluenceTh\"><div class=\"tablesorter-header-inner\"><p><br\/><\/p><\/div><\/th><\/tr><tr><td class=\"confluenceTd\"><p>Modalities<\/p><\/td><td class=\"confluenceTd\"><p>MR<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Patients<\/p><\/td><td class=\"confluenceTd\"><p>32<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Studies<\/p><\/td><td class=\"confluenceTd\"><p>149<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Series<\/p><\/td><td class=\"confluenceTd\"><p>205<\/p><\/td><\/tr><tr><td class=\"confluenceTd\"><p>Number of Images<\/p><\/td><td class=\"confluenceTd\"><p>23,487<\/p><\/td><\/tr><tr><td colspan=\"1\" class=\"confluenceTd\">Images Size (GB)<\/td><td colspan=\"1\" class=\"confluenceTd\">8.6<\/td><\/tr><\/tbody><\/table><\/div><p>A presentation about a related Mouse GBM data set can be found at:\u00a0<strong><a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/20644280\/Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt?version=1&amp;modificationDate=1426708064396&amp;api=v2\" data-linked-resource-id=\"20807725\" data-linked-resource-version=\"1\" data-linked-resource-type=\"attachment\" data-linked-resource-default-alias=\"Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt\" data-nice-type=\"PowerPoint Presentation\" data-linked-resource-content-type=\"application\/vnd.ms-powerpoint\" data-linked-resource-container-id=\"20644280\" data-linked-resource-container-version=\"75\">Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt<\/a><\/strong>.<\/p><\/div><div class=\"tabs-pane \" id=\"206442805e4347f12179400fa1daf8a7a7c383a9\" name=\"Citations BITVOODOO_ANDamp; Data Usage Policy\" ><h3 id=\"MouseMammary-Citations&amp;DataUsagePolicy\">Citations &amp; Data Usage Policy\u00a0<\/h3><p>\n<p>\nUsers must abide by the <a href=\"https:\/\/wiki.cancerimagingarchive.net\/x\/c4hF\" class=\"external-link\" rel=\"nofollow\">TCIA Data Usage Policy and Restrictions<\/a>. Attribution should include references to the following citations:\n<\/p><\/p><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">Data Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p><span style=\"color: rgb(102,102,102);\"><span style=\"color: rgb(0,0,0);\">Jansen, S., Ileva, L., Lu, L., &amp; Van Dyke, T.\u00a0(2015). <strong>TCIA Mouse-Mammary Collection (Mouse-Mammary) [Data set].<\/strong> The Cancer Imaging Archive.<\/span> <a href=\"https:\/\/doi.org\/10.7937\/K9\/TCIA.2015.9P42KSE6\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.7937\/K9\/TCIA.2015.9P42KSE6<\/a><\/span><\/p><\/div><\/div><div class=\"confluence-information-macro confluence-information-macro-information\"><p class=\"title\">TCIA Citation<\/p><span class=\"aui-icon aui-icon-small aui-iconfont-info confluence-information-macro-icon\"><\/span><div class=\"confluence-information-macro-body\"><p>Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, Tarbox L, Prior F. (2013) <strong>The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository<\/strong>, Journal of Digital Imaging, Volume 26, Number 6, pp 1045-1057. DOI: <a href=\"https:\/\/doi.org\/10.1007\/s10278-013-9622-7\" class=\"external-link\" rel=\"nofollow\">https:\/\/doi.org\/10.1007\/s10278-013-9622-7<\/a><\/p><\/div><\/div><h3 id=\"MouseMammary-OtherPublicationsUsingThisData\">Other Publications Using This Data<\/h3><p><span>TCIA maintains <\/span><a rel=\"nofollow\" href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\" class=\"external-link\">a list of publications<\/a><span> which leverage TCIA data. <\/span> If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\" class=\"external-link\" rel=\"nofollow\"> contact TCIA's Helpdesk<\/a>.<\/p><\/div><div class=\"tabs-pane \" id=\"20644280a4c274a1b9d94137bf6ffd5a54f4a0f3\" name=\"Versions\" ><h3 id=\"MouseMammary-Version1(Current):Updated2015\/03\/18\">Version 1 (Current): Updated 2015\/03\/18<\/h3><div class=\"table-wrap\"><table class=\"wrapped relative-table confluenceTable\" style=\"width: 37.2211%;\"><colgroup><col style=\"width: 38.5673%;\"\/><col style=\"width: 61.4327%;\"\/><\/colgroup><tbody><tr><th colspan=\"1\" class=\"confluenceTh\">Data Type<\/th><th colspan=\"1\" class=\"confluenceTh\">Download all or Query\/Filter<\/th><\/tr><tr><td colspan=\"1\" class=\"confluenceTd\">Images (8.6GB)<\/td><td colspan=\"1\" class=\"confluenceTd\"><div class=\"content-wrapper\"><p>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/wiki.cancerimagingarchive.net\/download\/attachments\/20644280\/TCIA_Mouse-Mammary_06-22-2015.tcia?version=1&amp;modificationDate=1534787010965&amp;api=v2\" rel=\"nofollow\"><button class=\"tcia-btn tcia-download-color\"><i class=\"fa fa-cloud-download\" \/> Download<\/button><\/a>\u00a0\n<\/span>\n\n<span class=\"confluence-embedded-file-wrapper confluence-embedded-manual-size\">\n   <a href=\"https:\/\/www.cancerimagingarchive.net\/nbia-search\/?CollectionCriteria=Mouse-mammary\" class=\"external-link\" rel=\"nofollow\"><button class=\"tcia-btn tcia-search-color\"><i class=\"fa fa-search\" \/> Search<\/button><\/a>\u00a0\n<\/span><br\/><\/p><p>(Download requires\u00a0the\u00a0<a href=\"https:\/\/wiki.cancerimagingarchive.net\/display\/NBIA\/Downloading+TCIA+Images\" rel=\"nofollow\">NBIA Data Retriever<\/a>)<\/p><p><span class=\"confluence-link\"><br\/><\/span><\/p><\/div><\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div><\/div><\/div><h3 id=\"MouseMammary-\"><strong><span style=\"color: rgb(255,0,0);\"><span style=\"color: rgb(0,0,0);\">\u00a0<\/span><\/span><\/strong><\/h3><\/div>\n<\/div>\n<div class=\"cell aside\" data-type=\"aside\">\n<div class=\"innerCell\">\n<p><br\/><\/p><\/div>\n<\/div>\n<\/div>\n<\/div>","versions":false,"additional_resources":"The NCI Cancer Research Data Commons (CRDC) provides access to additional data and a cloud-based data science infrastructure that connects data sets with analytics tools to allow users to share, integrate, analyze, and visualize cancer research data.\n \n<ul><li><a href=\"https:\/\/portal.imaging.datacommons.cancer.gov\/explore\/filters\/?collection_id=mouse_mammary\">Imaging Data Commons (IDC)<\/a> (Imaging Data)<\/li><\/ul>","cancer_locations":["Abdomen"],"collection_page_accessibility":"Public","publications_related":"","version_change_log":"","version_change_log_archived":"","analysis_results":"","collection_status":"Complete","publications_using":"TCIA maintains <a href=\"https:\/\/www.cancerimagingarchive.net\/publications\/\">a list of publications<\/a> which leverage TCIA data.  If you have a manuscript you'd like to add please<a href=\"http:\/\/www.cancerimagingarchive.net\/support\/\"> contact TCIA's Helpdesk<\/a>.","species":["Mouse"],"collection_title":"Mouse-Mammary","detailed_description":"A presentation about a related Mouse GBM data set can be found at:\u00a0<strong><a data-linked-resource-container-id=\"20644280\" data-linked-resource-container-version=\"75\" data-linked-resource-content-type=\"application\/vnd.ms-powerpoint\" data-linked-resource-default-alias=\"Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt\" data-linked-resource-id=\"20807725\" data-linked-resource-type=\"attachment\" data-linked-resource-version=\"1\" data-nice-type=\"PowerPoint Presentation\" download=\"\" href=\"\/wp-content\/uploads\/Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt\" target=\"_blank\">Sunny_jansen_NBIA_mouseGBM_update_ICR_508.ppt<\/a><\/strong>.","related_analysis_results":false,"subjects":"32","collection_short_title":"Mouse-Mammary","data_types":["MR"],"date_updated":"2023-09-13","collection_browse_title":"","supporting_data":false,"collection_featured_image":false,"collection_summary":"This collection consists of magnetic resonance images (MRI) of genetically engineered mouse models (GEMMs) of breast cancer.\u00a0 These images were acquired as part of a Department of Defense (DOD) Breast Cancer Research Program (BCRP) Postdoctoral Award W81XWH-12-1-0307 entitled \u201c<em>Investigating Ductal Carcinoma in Situ Using Noninvasive Imaging of Genetically Engineered Mouse Models<\/em>\nA particular emphasis of this project was to study the earliest stages of breast cancer\u2014preinvasive ductal carcinoma <em>in situ <\/em>(DCIS)\u2014and to interrogate the underlying genetic events that influence progression into invasive disease. In particular, we focused on the role of perturbed Rb, p53 and BRCA1 functionality and how these pathways, acting alone and in combination, can influence the development and progression of DCIS. GEMMs serve as an excellent model system wherein genetic changes can be controlled and manipulated over time.\u00a0 <em>In vivo<\/em> MRI is a superb technique for noninvasively tracking and characterizing these microscopic early stage cancers as they develop, change and transition into lethal invasive disease.\nFor scientific or other inquiries about this dataset, please <a href=\"https:\/\/www.cancerimagingarchive.net\/support\/\">contact TCIA's Helpdesk<\/a>.","collection_acknowledgements":"<strong>\u00a0<\/strong>We would like to acknowledge the individuals and institutions that have provided data for this collection:\n<ul><li><strong>\u00a0<\/strong><strong>National Cancer Institute (Frederick, Maryland) -\u00a0<\/strong>Special thanks to<strong>\u00a0Sunny Jansen, PhD<\/strong>\u00a0 from the Department of\u00a0<strong>Mouse Cancer Genetics Program.<\/strong><\/li><\/ul>\n<strong><br\/><\/strong>","collection_funding":"","hide_from_browse_table":[],"_links":{"self":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections\/5630"}],"collection":[{"href":"https:\/\/cm.vastapps.dev\/api\/v1\/collections"}],"about":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/types\/tcia_collection"}],"wp:attachment":[{"href":"https:\/\/cm.vastapps.dev\/api\/wp\/v2\/media?parent=5630"}],"wp:term":[{"taxonomy":"tcia_citation_tax","embeddable":true,"href":"https:\/\/cm.vastapps.dev\/api\/v1\/citation-tax?post=5630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}