The Cancer Genome Atlas Ovarian Cancer Collection (TCGA-OV)<\/a> patients with HGSOC prior to primary cytoreductive surgery. Two readers independently assessed the contrast-enhanced computed tomography (CT) images and extracted 33 imaging traits, with a third reader adjudicating in the event of a disagreement. In addition, all sites of suspected HGSOC were manually segmented texture features were computed from each tumour site. Three texture features that represented intra-and inter-site tumour heterogeneity were used for analysis. An integrated analysis of transcriptomic and proteomic data identified proteins with conserved expression between primary tumour sites and metastasis. Correlations between protein-abundance and various CT imaging traits and texture features were assessed using the Kendall tau rank correlation-coefficient and the Mann-Whitney U test, whereas the area under the receiver-operating characteristic curve (AUC) was reported as a metric of the strength and the direction of the association. p values < 0.05 were considered significant.<\/p>Results<\/h3>
Four proteins were associated with CT-based imaging traits, with the strongest correlation observed between the CRIP2 protein and disease in the mesentery (p<0.001, AUC=0.05). The abundance of three proteins was associated with texture features that represented intra-and inter-site tumour heterogeneity, with the strongest negative correlation between the CKB protein and cluster dissimilarity (p=0.047, \ud835\udf0f =0.326).<\/p>
Conclusion<\/h3>
This study provides the first insights into the potential associations between standard-of-care CT imaging traits and texture measures of intra-and inter-site heterogeneity, and the abundance of several proteins.<\/p>
<\/p>