{"id":5748,"date":"2023-09-04T03:35:26","date_gmt":"2023-09-04T03:35:26","guid":{"rendered":"https:\/\/cm.vastapps.dev\/tcia-analysis-result\/tcga-kirc-radiogenomics\/"},"modified":"2023-09-13T12:08:23","modified_gmt":"2023-09-13T12:08:23","slug":"tcga-kirc-radiogenomics","status":"publish","type":"tcia_analysis_result","link":"https:\/\/cm.vastapps.dev\/tcia-analysis-result\/tcga-kirc-radiogenomics\/","title":{"rendered":"TCGA-KIRC-RADIOGENOMICS"},"featured_media":0,"template":"","cancer_types":["Renal Clear Cell Carcinoma"],"citations":[4748,4749,2925],"full_export":"

Description<\/h2>

PURPOSE:<\/span><\/h4>

To investigate associations between imaging features and mutational status of clear cell renal cell carcinoma (ccRCC).<\/p>

MATERIALS AND METHODS:<\/h4>

This multi-institutional, multi-reader study included 103 patients (77 men; median age 59\u00a0years, range 34-79) with ccRCC examined with CT in 81 patients, MRI in 19, and both CT and MRI in three; images were downloaded from The Cancer Imaging Archive, an NCI-funded project for genome-mapping and analyses. Imaging features [size (mm), margin (well-defined or ill-defined), composition (solid or cystic), necrosis (for solid tumors: 0%, 1%-33%, 34%-66% or >66%), growth pattern (endophytic, <50% exophytic, or \u226550% exophytic), and calcification (present, absent, or indeterminate)] were reviewed independently by three readers blinded to mutational data. The association of imaging features with mutational status (VHL, BAP1, PBRM1, SETD2, KDM5C, and MUC4) was assessed.<\/p>

RESULTS:<\/h4>

Median tumor size was 49\u00a0mm (range 14-162\u00a0mm), 73 (71%) tumors had well-defined margins, 98 (95%) tumors were solid, 95 (92%) showed presence of necrosis, 46 (45%) had \u226550% exophytic component, and 18 (19.8%) had calcification. VHL (n\u00a0=\u00a052) and PBRM1 (n\u00a0=\u00a024) were the most common mutations. BAP1 mutation was associated with ill-defined margin and presence of calcification (p\u00a0=\u00a00.02 and 0.002, respectively, Pearson's \u03c7\u00a02<\/sup>\u00a0test); MUC4 mutation was associated with an exophytic growth pattern (p\u00a0=\u00a00.002, Mann-Whitney U test).<\/p>

CONCLUSIONS:<\/h4>

BAP1 mutation was associated with ill-defined tumor margins and presence of calcification; MUC4 mutation was associated with exophytic growth. Given the known prognostic implications of BAP1 and MUC4 mutations, these results support using radiogenomics to aid in prognostication and management.<\/p>

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